Protein Summary
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).
- ENST00000252050
- ENSP00000252050
- ENSG00000112659
- H7AP1
- KIAA0708
- PARC
- PARC
- H7AP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.91 | ||
tissue sample | 0.66 | ||
small molecule perturbation | 0.63 | ||
transcription factor perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.92 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 147 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.92 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 147 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (63)
TP53
Family: TF
Novelty: 0.00001907
p_int: 0.999999972
p_ni: 1.7e-8
p_wrong: 1.1e-8
Score: 0.681
Data Source: BioPlex,STRINGDB
GLMN
Novelty: 0.01940401
p_int: 0.999999694
p_ni: 3.05e-7
Score: 0.485
Data Source: BioPlex,STRINGDB
APEX2
Family: Enzyme
Novelty: 0.04076395
p_int: 0.999989158
p_ni: 0.000010841
p_wrong: 1e-9
Score: 0.208
Data Source: BioPlex,STRINGDB
RAB6B
Family: Enzyme
Novelty: 0.0865097
p_int: 0.999855453
p_ni: 0.000144401
p_wrong: 1.46e-7
Score: 0.161
Data Source: BioPlex,STRINGDB
TTC9C
Novelty: 0.85949913
p_int: 0.950755196
p_ni: 0.000764859
p_wrong: 0.048479945
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Neddylation | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Neddylation | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (4)
Components (2)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
age-related hearing impairment | 2 | 2 | 1 | 8.8 | 95.2 | ||||
glomerular filtration rate | 5 | 3 | 5 | 88.5 | |||||
creatinine measurement | 2 | 2 | 2 | 81.9 | |||||
testosterone measurement | 2 | 2 | 2 | 81.1 | |||||
urate measurement | 2 | 2 | 3 | 79.9 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
age-related hearing impairment | 1 | 8.8 | 95.2 | ||||
glomerular filtration rate | 5 | 88.5 | |||||
creatinine measurement | 2 | 81.9 | |||||
testosterone measurement | 2 | 81.1 | |||||
urate measurement | 3 | 79.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cullin 9 | VGNC:2680 | 463192 | |||||
Macaque | cullin 9 | 698984 | ||||||
Mouse | MGI:1925559 | 78309 | ||||||
Rat | RGD:1562008 | 316228 | ||||||
Dog | cullin 9 | VGNC:39735 | 481809 | |||||
Publication Statistics
PubMed Score 11.92
PubMed score by year
PubTator Score 282.91
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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