Protein Summary
Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745) ...more
- ENST00000265348
- ENSP00000265348
- ENSG00000044090
- ENST00000535468
- ENSP00000438788
- KIAA0076
- 3M1
- CUL-7
- KIAA0076
- dJ20C7.5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.92 | ||
protein domain | 0.92 | ||
transcription factor binding site profile | 0.79 | ||
phenotype | 0.63 | ||
cell line | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.46 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 171 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.46 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 171 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (327)
GLMN
Novelty: 0.01940401
p_int: 0.999999796
p_ni: 2.04e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
SKP1
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999999361
p_ni: 6.4e-7
Score: 0.981
Data Source: BioPlex,STRINGDB
MAPK14
Family: Kinase
Novelty: 0.00045138
p_int: 0.999998204
p_ni: 0.000001796
Score: 0.776
Data Source: BioPlex,STRINGDB
TP53
Family: TF
Novelty: 0.00001907
p_int: 0.999991499
p_ni: 0.000008501
Score: 0.661
Data Source: BioPlex,STRINGDB
KLHL2
Novelty: 0.07279226
p_int: 0.999955786
p_ni: 0.000044214
Score: 0.929
Data Source: BioPlex,STRINGDB
DGKG
Family: Enzyme
Novelty: 0.03666646
p_int: 0.999904325
p_ni: 0.000095675
Data Source: BioPlex
Nearest Tclin Targets
Pathways (12)
Reactome (10)
KEGG (1)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | IRE1alpha activates chaperones | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
IRE1alpha activates chaperones | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (1)
Components (8)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
apolipoprotein A 1 measurement | 2 | 3 | 3 | 92.7 | |||||
apolipoprotein B measurement | 2 | 3 | 3 | 86.8 | |||||
high density lipoprotein cholesterol measurement | 2 | 2 | 3 | 79.6 | |||||
bilirubin measurement | 1 | 1 | 1 | 67.3 | |||||
homocysteine measurement | 1 | 1 | 1 | 47.7 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
apolipoprotein A 1 measurement | 3 | 92.7 | |||||
apolipoprotein B measurement | 3 | 86.8 | |||||
high density lipoprotein cholesterol measurement | 3 | 79.6 | |||||
bilirubin measurement | 1 | 67.3 | |||||
homocysteine measurement | 1 | 47.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cullin 7 | VGNC:2679 | 472011 | |||||
Macaque | cullin 7 | 699545 | ||||||
Mouse | MGI:1913765 | 66515 | ||||||
Rat | RGD:1587048 | 680835 | ||||||
Horse | cullin 7 | VGNC:16972 | 100067262 | |||||
Publication Statistics
PubMed Score 58.46
PubMed score by year
PubTator Score 34.66
PubTator score by year
Related Publications
Text Mined References (50)
GeneRif Annotations (32)
Items per page:
0 of 0
PMID | Year | Title |
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