Protein Summary
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
- ENST00000393094
- ENSP00000376808
- ENSG00000166266
- ENST00000531427
- ENSP00000435376
- VACM1
- CUL-5
- VACM1
- VACM-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 1 | ||
transcription factor perturbation | 0.88 | ||
interacting protein | 0.86 | ||
molecular function | 0.86 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 125.79 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 218 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 125.79 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 218 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (405)
SOCS6
Novelty: 0.00993375
p_int: 0.999999999
p_ni: 1e-9
Score: 0.985
Data Source: BioPlex,STRINGDB
TULP4
Family: TF
Novelty: 0.05658032
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.924
Data Source: BioPlex,STRINGDB
LRRC28
Novelty: 0.65377588
p_int: 0.999999998
p_ni: 2e-9
Score: 0.223
Data Source: BioPlex,STRINGDB
RAB40B
Novelty: 0.2288213
p_int: 0.999999997
p_ni: 3e-9
Score: 0.791
Data Source: BioPlex,STRINGDB
ASB8
Novelty: 0.44680949
p_int: 0.999999994
p_ni: 6e-9
Score: 0.93
Data Source: BioPlex,STRINGDB
ASB1
Novelty: 0.0931554
p_int: 0.999999991
p_ni: 5e-9
p_wrong: 4e-9
Score: 0.971
Data Source: BioPlex,STRINGDB
SPSB2
Novelty: 0.07223184
p_int: 0.999999954
p_ni: 4.6e-8
Score: 0.957
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (21)
Reactome (16)
KEGG (2)
UniProt (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Disease | ||||
Reactome | Downregulation of ERBB2 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Disease | ||||
Downregulation of ERBB2 signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (4)
Components (3)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 1 | 1 | 78 | |||||
platelet crit | 1 | 1 | 1 | 77.9 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 58.4 | |||||
mosaic loss of chromosome Y measurement | 1 | 1 | 1 | 46.1 | |||||
platelet count | 1 | 1 | 1 | 32.7 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 78 | |||||
platelet crit | 1 | 77.9 | |||||
lymphocyte percentage of leukocytes | 1 | 58.4 | |||||
mosaic loss of chromosome Y measurement | 1 | 46.1 | |||||
platelet count | 1 | 32.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cullin 5 | VGNC:3137 | 466773 | |||||
Macaque | cullin 5 | 707559 | ||||||
Mouse | MGI:1922967 | 75717 | ||||||
Rat | RGD:621742 | 64624 | ||||||
Dog | cullin 5 | VGNC:39733 | 489422 | |||||
Publication Statistics
PubMed Score 125.79
PubMed score by year
PubTator Score 64.78
PubTator score by year
Related Publications
Text Mined References (72)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
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