Protein Summary
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
- ENST00000393094
- ENSP00000376808
- ENSG00000166266
- ENST00000531427
- ENSP00000435376
- VACM1
- CUL-5
- VACM1
- VACM-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 1 | ||
transcription factor perturbation | 0.88 | ||
interacting protein | 0.86 | ||
molecular function | 0.86 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 125.79 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 218 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 125.79 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 218 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (405)
SOCS6
Novelty: 0.00993375
p_int: 0.999999999
p_ni: 1e-9
Score: 0.985
Data Source: BioPlex,STRINGDB
TULP4
Family: TF
Novelty: 0.05658032
p_int: 0.999999999
p_wrong: 1e-9
Score: 0.924
Data Source: BioPlex,STRINGDB
LRRC28
Novelty: 0.65377588
p_int: 0.999999998
p_ni: 2e-9
Score: 0.223
Data Source: BioPlex,STRINGDB
RAB40B
Novelty: 0.2288213
p_int: 0.999999997
p_ni: 3e-9
Score: 0.791
Data Source: BioPlex,STRINGDB
ASB8
Novelty: 0.44680949
p_int: 0.999999994
p_ni: 6e-9
Score: 0.93
Data Source: BioPlex,STRINGDB
ASB1
Novelty: 0.0931554
p_int: 0.999999991
p_ni: 5e-9
p_wrong: 4e-9
Score: 0.971
Data Source: BioPlex,STRINGDB
SPSB2
Novelty: 0.07223184
p_int: 0.999999954
p_ni: 4.6e-8
Score: 0.957
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (21)
Reactome (16)
KEGG (2)
UniProt (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Disease | ||||
Reactome | Downregulation of ERBB2 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Disease | ||||
Downregulation of ERBB2 signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (4)
Components (3)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 1 | 1 | 78 | |||||
platelet crit | 1 | 1 | 1 | 77.9 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 58.4 | |||||
mosaic loss of chromosome Y measurement | 1 | 1 | 1 | 46.1 | |||||
platelet count | 1 | 1 | 1 | 32.7 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 78 | |||||
platelet crit | 1 | 77.9 | |||||
lymphocyte percentage of leukocytes | 1 | 58.4 | |||||
mosaic loss of chromosome Y measurement | 1 | 46.1 | |||||
platelet count | 1 | 32.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cullin 5 | VGNC:3137 | 466773 | |||||
Macaque | cullin 5 | 707559 | ||||||
Mouse | MGI:1922967 | 75717 | ||||||
Rat | RGD:621742 | 64624 | ||||||
Dog | cullin 5 | VGNC:39733 | 489422 | |||||
Publication Statistics
PubMed Score 125.79
PubMed score by year
PubTator Score 64.78
PubTator score by year
Related Publications
Text Mined References (72)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
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