Protein Summary
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dep ...more
- ENST00000375440
- ENSP00000364589
- ENSG00000139842
- ENST00000375441
- ENSP00000364590
- ENST00000451881
- ENSP00000389118
- ENST00000617546
- ENSP00000481782
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.98 | ||
transcription factor binding site profile | 0.9 | ||
biological process | 0.86 | ||
protein domain | 0.85 | ||
protein complex | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 110.86 (req: < 5)
Gene RIFs: 85 (req: <= 3)
Antibodies: 357 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 110.86 (req: >= 5)
Gene RIFs: 85 (req: > 3)
Antibodies: 357 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 9
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (9)
Protein-Protein Interactions (295)
DCAF4
Novelty: 0.24190895
p_int: 0.999929357
p_ni: 0.000070643
Score: 0.985
Data Source: BioPlex,STRINGDB
DCAF8
Novelty: 0.12456534
p_int: 0.999925487
p_ni: 0.000074513
Score: 0.934
Data Source: BioPlex,STRINGDB
DCAF11
Novelty: 0.08318661
p_int: 0.999923934
p_ni: 0.000076066
Score: 0.989
Data Source: BioPlex,STRINGDB
DDB2
Novelty: 0.00648809
p_int: 0.999896428
p_ni: 0.000103572
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
WDTC1
Novelty: 0.02300849
p_int: 0.999891733
p_ni: 0.000108267
Score: 0.935
Data Source: BioPlex,STRINGDB
DET1
Novelty: 0.01138079
p_int: 0.999791477
p_ni: 0.000208523
Score: 0.993
Data Source: BioPlex,STRINGDB
TRPC4AP
Novelty: 0.02170224
p_int: 0.999678712
p_ni: 0.000321288
Score: 0.939
Data Source: BioPlex,STRINGDB
COPS8
Novelty: 0.0408885
p_int: 0.999640855
p_ni: 0.000359145
Score: 0.987
Data Source: BioPlex,STRINGDB
DTL
Novelty: 0.01659105
p_int: 0.999335019
p_ni: 0.000664981
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (48)
Reactome (15)
KEGG (3)
UniProt (1)
WikiPathways (29)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | DNA Damage Bypass | ||||
Reactome | DNA Damage Recognition in GG-NER | ||||
Reactome | DNA Repair | ||||
Reactome | Dual Incision in GG-NER | ||||
Reactome | Dual incision in TC-NER | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
DNA Damage Bypass | ||||
DNA Damage Recognition in GG-NER | ||||
DNA Repair | ||||
Dual Incision in GG-NER | ||||
Dual incision in TC-NER | ||||
Viral Interactions (0)
Gene Ontology Terms (32)
Functions (1)
Components (4)
Processes (27)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 5 | 7 | 8 | 99.3 | |||||
prothrombin time measurement | 1 | 3 | 3 | 98 | |||||
platelet count | 2 | 3 | 3 | 95.8 | |||||
factor VII measurement | 1 | 1 | 1 | 88.6 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 76.5 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean platelet volume | 8 | 99.3 | |||||
prothrombin time measurement | 3 | 98 | |||||
platelet count | 3 | 95.8 | |||||
factor VII measurement | 1 | 88.6 | |||||
mean corpuscular hemoglobin concentration | 1 | 76.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cullin 4A | VGNC:5050 | 107968010 | |||||
Macaque | cullin 4A | 714302 | ||||||
Mouse | MGI:1914487 | 99375 | ||||||
Rat | RGD:1563853 | 361181 | ||||||
Dog | cullin 4A | VGNC:39731 | 607683 | |||||
Publication Statistics
PubMed Score 110.86
PubMed score by year
PubTator Score 80.95
PubTator score by year
Related Publications
Text Mined References (122)
GeneRif Annotations (85)
Items per page:
0 of 0
PMID | Year | Title |
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