Protein Summary
Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component. BCR(KLHL42) is involved in ubiquitination of KATNA1. BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, H2AFY and DAXX, GLI2 and GLI3. Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex co ...more
- ENST00000264414
- ENSP00000264414
- ENSG00000036257
- ENST00000344951
- ENSP00000343601
- ENST00000409096
- ENSP00000387200
- ENST00000409777
- ENSP00000386525
- KIAA0617
- CUL-3
- PHA2E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 1 | ||
biological process | 0.98 | ||
kinase perturbation | 0.88 | ||
drug perturbation | 0.87 | ||
hub protein | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 322.87 (req: < 5)
Gene RIFs: 73 (req: <= 3)
Antibodies: 362 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 322.87 (req: >= 5)
Gene RIFs: 73 (req: > 3)
Antibodies: 362 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 40
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (569)
LRRC42
Novelty: 1.83168269
p_int: 0.999999825
p_ni: 1.75e-7
Score: 0.186
Data Source: BioPlex,STRINGDB
KLHL8
Novelty: 0.4838314
p_int: 0.999999523
p_ni: 4.76e-7
p_wrong: 1e-9
Score: 0.79
Data Source: BioPlex,STRINGDB
KLHL21
Novelty: 0.20694121
p_int: 0.999999488
p_ni: 5.1e-7
p_wrong: 1e-9
Score: 0.984
Data Source: BioPlex,STRINGDB
KLHL25
Novelty: 0.14475787
p_int: 0.99999919
p_ni: 8.1e-7
Score: 0.976
Data Source: BioPlex,STRINGDB
KCTD20
Novelty: 0.47655751
p_int: 0.999999103
p_ni: 8.96e-7
p_wrong: 1e-9
Score: 0.256
Data Source: BioPlex,STRINGDB
KLHL18
Novelty: 0.52915213
p_int: 0.999998933
p_ni: 0.000001067
Score: 0.718
Data Source: BioPlex,STRINGDB
ANKRD39
Novelty: 8.68843298
p_int: 0.99999872
p_ni: 5e-9
p_wrong: 0.000001276
Score: 0.361
Data Source: BioPlex,STRINGDB
KLHL7
Novelty: 0.0522116
p_int: 0.9999986
p_ni: 0.0000014
Score: 0.702
Data Source: BioPlex,STRINGDB
BTBD10
Novelty: 0.23077172
p_int: 0.999998488
p_ni: 0.00000151
p_wrong: 1e-9
Score: 0.235
Data Source: BioPlex,STRINGDB
KLHL42
Novelty: 0.25822395
p_int: 0.999997975
p_ni: 0.000002025
Score: 0.977
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (30)
Reactome (21)
KEGG (2)
PathwayCommons (3)
UniProt (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Degradation of DVL | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Cytokine Signaling in Immune system | ||||
Degradation of DVL | ||||
Viral Interactions (0)
Gene Ontology Terms (50)
Functions (6)
Components (10)
Processes (34)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | MGI | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 3 | 5 | 83.2 | |||||
smoking initiation | 2 | 2 | 2 | 75 | |||||
smoking status measurement | 2 | 1 | 2 | 68.8 | |||||
risk-taking behaviour | 1 | 1 | 1 | 66.3 | |||||
alcohol consumption measurement | 3 | 2 | 3 | 61.9 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mathematical ability | 5 | 83.2 | |||||
smoking initiation | 2 | 75 | |||||
smoking status measurement | 2 | 68.8 | |||||
risk-taking behaviour | 1 | 66.3 | |||||
alcohol consumption measurement | 3 | 61.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cullin 3 | VGNC:152 | 744812 | |||||
Macaque | cullin 3 | 707550 | ||||||
Mouse | MGI:1347360 | 26554 | ||||||
Rat | RGD:1308190 | 301555 | ||||||
Dog | cullin 3 | VGNC:39730 | 477392 | |||||
Publication Statistics
PubMed Score 322.87
PubMed score by year
PubTator Score 165.88
PubTator score by year
Related Publications
Text Mined References (130)
GeneRif Annotations (73)
Items per page:
0 of 0
PMID | Year | Title |
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