Protein Summary
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
- ENST00000374748
- ENSP00000363880
- ENSG00000108094
- ENST00000374749
- ENSP00000363881
- ENST00000374751
- ENSP00000363883
- ENST00000421317
- ENSP00000414095
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.93 | ||
interacting protein | 0.93 | ||
protein domain | 0.85 | ||
microRNA | 0.73 | ||
transcription factor | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 186.1 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 454 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 186.1 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 454 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (455)
LRRC14
Novelty: 0.67398865
p_int: 0.999999992
p_ni: 8e-9
Score: 0.176
Data Source: BioPlex,STRINGDB
FEM1C
Novelty: 0.09385738
p_int: 0.999999973
p_ni: 2.2e-8
p_wrong: 5e-9
Score: 0.963
Data Source: BioPlex,STRINGDB
KLHDC10
Novelty: 0.40978227
p_int: 0.999985242
p_ni: 0.000002824
p_wrong: 0.000011934
Score: 0.59
Data Source: BioPlex,STRINGDB
APPBP2
Novelty: 0.14742368
p_int: 0.999969541
p_ni: 0.000030459
Score: 0.242
Data Source: BioPlex,STRINGDB
FEM1B
Novelty: 0.06746412
p_int: 0.999965039
p_ni: 0.000034961
Score: 0.977
Data Source: BioPlex,STRINGDB
VHL
Family: Enzyme
Novelty: 0.00285782
p_int: 0.999930261
p_ni: 0.000069716
p_wrong: 2.3e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ANKRD39
Novelty: 8.68843298
p_int: 0.999930125
p_ni: 0.000051693
p_wrong: 0.000018182
Score: 0.203
Data Source: BioPlex,STRINGDB
LRR1
Novelty: 0.02407468
p_int: 0.999923359
p_ni: 0.000075943
p_wrong: 6.98e-7
Score: 0.968
Data Source: BioPlex,STRINGDB
KLHDC3
Novelty: 0.63840156
p_int: 0.999877352
p_ni: 0.00012238
p_wrong: 2.68e-7
Score: 0.796
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (53)
Reactome (15)
KEGG (4)
PathwayCommons (1)
UniProt (1)
WikiPathways (32)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Axon guidance | ||||
Reactome | Cellular response to hypoxia | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Axon guidance | ||||
Cellular response to hypoxia | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (2)
Components (6)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.2 | 79.3 | |||||
eosinophil count | 2 | 2 | 2 | 64.3 | |||||
2 | 1 | 0 | 1.1 | 37.5 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 12.6 | |||||
1 | 1 | 0 | 1.1 | 3.9 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.2 | 79.3 | |||||
eosinophil count | 2 | 64.3 | |||||
0 | 1.1 | 37.5 | |||||
eosinophil percentage of leukocytes | 1 | 12.6 | |||||
0 | 1.1 | 3.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cullin 2 | VGNC:5386 | 107976958 | |||||
Macaque | cullin 2 | 698384 | ||||||
Mouse | MGI:1918995 | 71745 | ||||||
Rat | RGD:1310644 | 361258 | ||||||
Dog | cullin 2 | VGNC:39729 | 477952 | |||||
Publication Statistics
PubMed Score 186.10
PubMed score by year
PubTator Score 87.80
PubTator score by year
Related Publications
Text Mined References (57)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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