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Tbio
CUEDC2
CUE domain-containing protein 2

Protein Summary
Description
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369937
  • ENSP00000358953
  • ENSG00000107874

Symbol
  • C10orf66
  • C10orf66
  • bA18I14.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor binding site profile
0.9
tissue sample
0.67
transcription factor
0.64
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.85   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.85   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
FZR1
Tbio
Novelty:  0.01599606
p_int:  1
Score:  0.347
Data Source:  BioPlex,STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.999990637
p_ni:  0.000009317
p_wrong:  4.5e-8
Data Source:  BioPlex
GTF2A2
Tbio
Novelty:  0.03391028
p_int:  0.999979514
p_ni:  0.00001477
p_wrong:  0.000005716
Data Source:  BioPlex
RNF26
Tbio
Novelty:  0.40088751
p_int:  0.998548387
p_ni:  0.000482909
p_wrong:  0.000968703
Score:  0.197
Data Source:  BioPlex,STRINGDB
NAB2
Tbio
Novelty:  0.00860107
p_int:  0.986782299
p_ni:  0.013177241
p_wrong:  0.00004046
Score:  0.197
Data Source:  BioPlex,STRINGDB
TBP
Tbio
Novelty:  0.00034941
p_int:  0.973702691
p_ni:  0.026297309
Score:  0.871
Data Source:  BioPlex,STRINGDB
KHK
Tchem
Family:  Kinase
Novelty:  0.00514172
p_int:  0.927536558
p_ni:  0.072461777
p_wrong:  0.000001664
Score:  0.416
Data Source:  BioPlex,STRINGDB
GTF2A1
Tchem
Novelty:  0.19577296
Score:  0.848
Data Source:  STRINGDB
PPP1R15A
Tchem
Family:  Enzyme
Novelty:  0.00529607
Score:  0.747
Data Source:  STRINGDB
CUEDC1
Tbio
Novelty:  0.14401061
Score:  0.727
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Regulation of toll-like receptor signaling pathway
WikiPathways
Regulation of toll-like receptor signaling pathway
WikiPathways
Regulation of toll-like receptor signaling pathway
WikiPathways
TLR4 Signaling and Tolerance
WikiPathways
Toll-like Receptor Signaling
Name
Explore in Pharos
Explore in Source
Regulation of toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathway
Regulation of toll-like receptor signaling pathway
TLR4 Signaling and Tolerance
Toll-like Receptor Signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1
81.4
4
3
2
1
78.6
platelet crit
1
1
1
64.4
1
1
0
1.1
63.4
age at onset
1
1
1
62.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
81.4
2
1
78.6
platelet crit
1
64.4
0
1.1
63.4
age at onset
1
62.6
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CUE domain containing 2
VGNC:2468
745600
Macaque
CUE domain containing 2
713243
Mouse
MGI:1914366
67116
Rat
RGD:1308096
294009
Dog
CUE domain containing 2
VGNC:39727
100855631
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CUE domain containing 2
Macaque
CUE domain containing 2
Mouse
Rat
Dog
CUE domain containing 2
Publication Statistics
PubMed Score 22.85
PubMed score by year
PubTator Score 10.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title