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Tdark
CTU2
Cytoplasmic tRNA 2-thiolation protein 2

Protein Summary
Description
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. This gene encodes a protein which is involved in the post-transcriptional modification of transfer RNAs (tRNAs). The encoded protein plays a role in thiolation of uridine residue present at the wobble position in a subset of tRNAs, resulting in enhanced codon reading accuracy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312060
  • ENSP00000308617
  • ENSG00000174177
  • ENST00000453996
  • ENSP00000388320

Symbol
  • C16orf84
  • NCS2
  • MFRG
  • NCS2
  • UPF0432
  • C16orf84
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.68
cell line
0.63
tissue sample
0.63
transcription factor binding site profile
0.6
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.67   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 19   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.67   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
LBHD1
Tdark
Novelty:  7.69709763
p_int:  0.997274633
p_ni:  0.002725367
Score:  0.169
Data Source:  BioPlex,STRINGDB
TINAG
Tbio
Novelty:  0.04582927
p_int:  0.994865536
p_ni:  0.005134464
Data Source:  BioPlex
SCPEP1
Tbio
Family:  Enzyme
Novelty:  0.08603794
p_int:  0.992985705
p_ni:  0.007014294
p_wrong:  1e-9
Data Source:  BioPlex
MYCL
Tbio
Family:  TF
Novelty:  0.0034508
p_int:  0.987067533
p_ni:  0.012932467
Data Source:  BioPlex
THUMPD3
Tdark
Novelty:  0.23224828
p_int:  0.966379166
p_ni:  0.033620834
Score:  0.176
Data Source:  BioPlex,STRINGDB
PAFAH2
Tbio
Family:  Enzyme
Novelty:  0.19881779
p_int:  0.957353941
p_ni:  0.042646035
p_wrong:  2.4e-8
Data Source:  BioPlex
ZMAT5
Tdark
Novelty:  0.97115324
p_int:  0.950170017
p_ni:  0.049829983
Data Source:  BioPlex
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.940353986
p_ni:  0.05964597
p_wrong:  4.4e-8
Data Source:  BioPlex
PFDN4
Tbio
Novelty:  0.02133605
p_int:  0.93157936
p_ni:  0.06842064
Data Source:  BioPlex
POLM
Tbio
Family:  Enzyme
Novelty:  0.00362931
p_int:  0.920836162
p_ni:  0.079163838
Score:  0.204
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
6
10
11
99.3
hemoglobin measurement
7
9
12
98.6
mean corpuscular hemoglobin concentration
9
5
11
98.3
hematocrit
5
7
8
96.9
Varicose veins
1
1
1
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
11
99.3
hemoglobin measurement
12
98.6
mean corpuscular hemoglobin concentration
11
98.3
hematocrit
8
96.9
Varicose veins
1
92.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytosolic thiouridylase subunit 2
VGNC:9077
736021
Macaque
cytosolic thiouridylase subunit 2
100424255
Mouse
MGI:1914215
66965
Rat
RGD:1562594
292069
Dog
cytosolic thiouridylase subunit 2
VGNC:39721
479617
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytosolic thiouridylase subunit 2
Macaque
cytosolic thiouridylase subunit 2
Mouse
Rat
Dog
cytosolic thiouridylase subunit 2
Publication Statistics
PubMed Score 142.67
PubMed score by year
PubTator Score 146.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title