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Tbio
CTU1
Cytoplasmic tRNA 2-thiolation protein 1

Protein Summary
Description
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000421832
  • ENSP00000390011
  • ENSG00000142544

Symbol
  • ATPBD3
  • NCS6
  • NCS6
  • ATPBD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
transcription factor binding site profile
0.78
transcription factor
0.59
protein domain
0.58
tissue sample
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.23   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.23   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
SCPEP1
Tbio
Family:  Enzyme
Novelty:  0.08603794
p_int:  0.999925911
p_ni:  0.000074089
Data Source:  BioPlex
TINAG
Tbio
Novelty:  0.04582927
p_int:  0.956825108
p_ni:  0.043174834
p_wrong:  5.8e-8
Data Source:  BioPlex
PLA2G10
Tchem
Family:  Enzyme
Novelty:  0.00289317
p_int:  0.932260906
p_ni:  0.067739093
Data Source:  BioPlex
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.932136852
p_ni:  0.067849609
p_wrong:  0.000013539
Data Source:  BioPlex
SCRN1
Tbio
Family:  Enzyme
Novelty:  0.08315012
p_int:  0.925048474
p_ni:  0.07495152
p_wrong:  6e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
LBHD1
Tdark
Novelty:  7.69709763
p_int:  0.909030202
p_ni:  0.090969792
p_wrong:  6e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
MYCL
Tbio
Family:  TF
Novelty:  0.0034508
p_int:  0.895398503
p_ni:  0.104601487
p_wrong:  9e-9
Data Source:  BioPlex
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.893408765
p_ni:  0.106591228
p_wrong:  7e-9
Data Source:  BioPlex
MAGEA1
Tbio
Novelty:  0.00506874
p_int:  0.885431368
p_ni:  0.114568619
p_wrong:  1.2e-8
Data Source:  BioPlex
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.873397355
p_ni:  0.11189999
p_wrong:  0.014702655
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
3
5
91.6
blood protein measurement
1
1
1
86.5
kallikrein-11 measurement
1
1
0
1.5
69.5
C-reactive protein measurement
1
1
1
38.8
monocyte percentage of leukocytes
2
1
2
37.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
91.6
blood protein measurement
1
86.5
kallikrein-11 measurement
0
1.5
69.5
C-reactive protein measurement
1
38.8
monocyte percentage of leukocytes
2
37.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytosolic thiouridylase subunit 1
VGNC:2377
456240
Mouse
MGI:2385277
233189
Rat
RGD:1308740
292847
Dog
cytosolic thiouridylase subunit 1
611758
Cow
cytosolic thiouridylase subunit 1
522824
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytosolic thiouridylase subunit 1
Mouse
Rat
Dog
cytosolic thiouridylase subunit 1
Cow
cytosolic thiouridylase subunit 1
Publication Statistics
PubMed Score 21.23
PubMed score by year
PubTator Score 29.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title