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Tbio
CTSO
Cathepsin O

Protein Summary
Description
Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433477
  • ENSP00000414904
  • ENSG00000256043
  • ENST00000573499
  • ENSP00000460395
  • ENSG00000263238

Symbol
  • CTSO1
  • CTSO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.86
microRNA
0.59
protein domain
0.58
cell type or tissue
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.3   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.3   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
KNG1
Tbio
Novelty:  0.00007684
p_int:  0.999990261
p_ni:  0.000009734
p_wrong:  5e-9
Score:  0.206
Data Source:  BioPlex,STRINGDB
LYPLA1
Tchem
Family:  Enzyme
Novelty:  0.01217068
p_int:  0.999749531
p_ni:  0.000184712
p_wrong:  0.000065758
Score:  0.517
Data Source:  BioPlex,STRINGDB
GRN
Tbio
Novelty:  0.00096395
p_int:  0.999164815
p_ni:  0.000835185
Score:  0.446
Data Source:  BioPlex,STRINGDB
CSTA
Tbio
Novelty:  0.00453121
p_int:  0.998751014
p_ni:  0.000004231
p_wrong:  0.001244755
Score:  0.302
Data Source:  BioPlex,STRINGDB
CD74
Tchem
Novelty:  0.00281228
Score:  0.922
Data Source:  STRINGDB
HLA-DPA1
Tbio
Novelty:  0.01080446
Score:  0.909
Data Source:  STRINGDB
P04229
Tbio
Novelty:  0.00240724
Score:  0.908
Data Source:  STRINGDB
Q95IE3
Tbio
Novelty:  0.00240724
Score:  0.908
Data Source:  STRINGDB
HLA-DRA
Tbio
Novelty:  0.0060214
Score:  0.908
Data Source:  STRINGDB
P13761
Tbio
Novelty:  0.00240724
Score:  0.908
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
MHC class II antigen presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
MHC class II antigen presentation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tryptophan measurement
1
1
0
12.9
86.5
tryptophan measurement
1
1
0
12.9
86.5
blood metabolite measurement
1
1
1
58.5
blood metabolite measurement
1
1
1
58.5
blood protein measurement
1
1
1
49.3
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tryptophan measurement
0
12.9
86.5
tryptophan measurement
0
12.9
86.5
blood metabolite measurement
1
58.5
blood metabolite measurement
1
58.5
blood protein measurement
1
49.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cathepsin O
VGNC:10852
461567
Macaque
cathepsin O
699868
Mouse
MGI:2139628
229445
Dog
cathepsin O
VGNC:54198
482665
Horse
cathepsin O
VGNC:16954
100069500
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cathepsin O
Macaque
cathepsin O
Mouse
Dog
cathepsin O
Horse
cathepsin O
Publication Statistics
PubMed Score 14.30
PubMed score by year
PubTator Score 8.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title