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Tchem
CTSK
Cathepsin K

Protein Summary
Description
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271651
  • ENSP00000271651
  • ENSG00000143387

Symbol
  • CTSO
  • CTSO2
  • CTSO
  • PKND
  • PYCD
  • CTS02
  • CTSO1
  • CTSO2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological term
0.84
cellular component
0.8
drug
0.79
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1493.27   (req: < 5)
Gene RIFs: 128   (req: <= 3)
Antibodies: 548   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1493.27   (req: >= 5)
Gene RIFs: 128   (req: > 3)
Antibodies: 548   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1459
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2