Protein Summary
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride. The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]
- ENST00000216336
- ENSP00000216336
- ENSG00000100448
- CG
- CATG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.8 | ||
gene perturbation | 0.77 | ||
biological process | 0.7 | ||
cellular component | 0.7 | ||
biological term | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 930.74 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 370 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 930.74 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 370 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 93
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (93)
Protein-Protein Interactions (204)
RPS27A
Novelty: 0.00658124
p_int: 0.998153228
p_ni: 0.001846772
Score: 0.271
Data Source: BioPlex,STRINGDB
ICE2
Novelty: 0.03407933
p_int: 0.997057396
p_ni: 3.66e-7
p_wrong: 0.002942238
Score: 0.163
Data Source: BioPlex,STRINGDB
GPRASP2
Novelty: 0.14060209
p_int: 0.968165532
p_ni: 0.031834468
Score: 0.816
Data Source: BioPlex,STRINGDB
TCF25
Novelty: 0.08961823
p_int: 0.930688229
p_ni: 0.069311771
Score: 0.787
Data Source: BioPlex,STRINGDB
YTHDF1
Novelty: 0.02063275
p_int: 0.912227465
p_ni: 0.087772534
Score: 0.179
Data Source: BioPlex,STRINGDB
PSMG3
Novelty: 0.01730294
p_int: 0.89608867
p_ni: 0.103905536
p_wrong: 0.000005795
Data Source: BioPlex
WIZ
Family: TF
Novelty: 0.04458547
p_int: 0.886042715
p_ni: 0.113957285
Score: 0.198
Data Source: BioPlex,STRINGDB
FREM2
Novelty: 0.03382033
p_int: 0.857897936
p_ni: 0.142102064
Score: 0.163
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (34)
Reactome (15)
KEGG (5)
PathwayCommons (1)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Antimicrobial peptides | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Antimicrobial peptides | ||||
Cytokine Signaling in Immune system | ||||
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (4)
Components (11)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 1 | 0 | 1.3 | 65.3 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 65.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cathepsin G | VGNC:3447 | 467413 | |||||
Macaque | cathepsin G | 716440 | ||||||
Mouse | MGI:88563 | 13035 | ||||||
Rat | RGD:1307681 | 290257 | ||||||
Dog | cathepsin G | VGNC:39712 | 106559147 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cathepsin G | |||||
Macaque | cathepsin G | |||||
Mouse | ||||||
Rat | ||||||
Dog | cathepsin G | |||||
Publication Statistics
PubMed Score 930.74
PubMed score by year
PubTator Score 783.54
PubTator score by year
Related Publications
Text Mined References (124)
GeneRif Annotations (55)
Items per page:
0 of 0
PMID | Year | Title |
|---|