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Tchem
CTSG
Cathepsin G

Protein Summary
Description
Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride. The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216336
  • ENSP00000216336
  • ENSG00000100448

Symbol
  • CG
  • CATG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
gene perturbation
0.77
biological process
0.7
cellular component
0.7
biological term
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 930.74   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 370   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 930.74   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 370   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 93
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (93)
Peptide boronate
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Peptide boronate
Rendered image for Peptide boronate
Peptide boronate
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Peptide boronate
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Peptide boronate
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Peptide boronate
Rendered image for Peptide boronate
Delanzomib
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Peptide boronate
Rendered image for Peptide boronate
Peptide boronate
Rendered image for Peptide boronate
Protein-Protein Interactions (204)
RPS27A
Tbio
Novelty:  0.00658124
p_int:  0.998153228
p_ni:  0.001846772
Score:  0.271
Data Source:  BioPlex,STRINGDB
ICE2
Tbio
Novelty:  0.03407933
p_int:  0.997057396
p_ni:  3.66e-7
p_wrong:  0.002942238
Score:  0.163
Data Source:  BioPlex,STRINGDB
GPRASP2
Tbio
Novelty:  0.14060209
p_int:  0.968165532
p_ni:  0.031834468
Score:  0.816
Data Source:  BioPlex,STRINGDB
TCF25
Tbio
Novelty:  0.08961823
p_int:  0.930688229
p_ni:  0.069311771
Score:  0.787
Data Source:  BioPlex,STRINGDB
YTHDF1
Tbio
Novelty:  0.02063275
p_int:  0.912227465
p_ni:  0.087772534
Score:  0.179
Data Source:  BioPlex,STRINGDB
PSMG3
Tchem
Novelty:  0.01730294
p_int:  0.89608867
p_ni:  0.103905536
p_wrong:  0.000005795
Data Source:  BioPlex
WIZ
Tbio
Family:  TF
Novelty:  0.04458547
p_int:  0.886042715
p_ni:  0.113957285
Score:  0.198
Data Source:  BioPlex,STRINGDB
FREM2
Tbio
Novelty:  0.03382033
p_int:  0.857897936
p_ni:  0.142102064
Score:  0.163
Data Source:  BioPlex,STRINGDB
MPO
Tchem
Family:  Enzyme
Novelty:  0.00020698
Score:  0.989
Data Source:  STRINGDB
ELANE
Tclin
Family:  Enzyme
Novelty:  0.00026112
Score:  0.982
Data Source:  STRINGDB
Pathways (34)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

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Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Antimicrobial peptides
Reactome
Cytokine Signaling in Immune system
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Antimicrobial peptides
Cytokine Signaling in Immune system
Degradation of the extracellular matrix
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.3
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
65.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cathepsin G
VGNC:3447
467413
Macaque
cathepsin G
716440
Mouse
MGI:88563
13035
Rat
RGD:1307681
290257
Dog
cathepsin G
VGNC:39712
106559147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cathepsin G
Macaque
cathepsin G
Mouse
Rat
Dog
cathepsin G
Publication Statistics
PubMed Score 930.74
PubMed score by year
PubTator Score 783.54
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title