Protein Summary
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015]
- ENST00000358184
- ENSP00000350911
- ENSG00000196188
- ENST00000360218
- ENSP00000353350
- CATE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.74 | ||
cellular component | 0.71 | ||
phenotype | 0.7 | ||
disease | 0.62 | ||
gene perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 247.31 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 266 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 247.31 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 266 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 62
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (62)
Protein-Protein Interactions (67)
MTMR9
Novelty: 0.09702778
p_int: 0.999598921
p_ni: 0.000388403
p_wrong: 0.000012676
Score: 0.679
Data Source: BioPlex,STRINGDB
KCTD6
Novelty: 0.43478298
p_int: 0.986614278
p_ni: 0.003787624
p_wrong: 0.009598098
Score: 0.254
Data Source: BioPlex,STRINGDB
MTMR6
Family: Enzyme
Novelty: 0.13067072
p_int: 0.974328909
p_ni: 0.025280282
p_wrong: 0.000390809
Score: 0.71
Data Source: BioPlex,STRINGDB
CCNT1
Novelty: 0.00526848
p_int: 0.890478217
p_ni: 0.106169948
p_wrong: 0.003351834
Score: 0.194
Data Source: BioPlex,STRINGDB
B3GLCT
Family: Enzyme
Novelty: 0.02398944
p_int: 0.870755025
p_ni: 0.129244974
p_wrong: 1e-9
Score: 0.25
Data Source: BioPlex,STRINGDB
CHEK1
Family: Kinase
Novelty: 0.00066843
p_int: 0.868895006
p_ni: 0.131104994
Score: 0.173
Data Source: BioPlex,STRINGDB
GNB2
Novelty: 0.08682553
p_int: 0.838690526
p_ni: 0.161309473
p_wrong: 2e-9
Score: 0.244
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Immune System | ||||
Reactome | MHC class II antigen presentation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Immune System | ||||
MHC class II antigen presentation | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (1)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cystic fibrosis associated meconium ileus | 1 | 1 | 0 | 1.4 | 48.5 | ||||
1 | 1 | 0 | 1.4 | 7.9 | |||||
1 | 1 | 0 | 1.4 | 7.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cystic fibrosis associated meconium ileus | 0 | 1.4 | 48.5 | ||||
0 | 1.4 | 7.9 | |||||
0 | 1.4 | 7.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cathepsin E | VGNC:514 | 457677 | |||||
Macaque | cathepsin E | 696202 | ||||||
Mouse | MGI:107361 | 13034 | ||||||
Rat | RGD:2446 | 25424 | ||||||
Dog | cathepsin E | VGNC:39710 | 488577 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cathepsin E | |||||
Macaque | cathepsin E | |||||
Mouse | ||||||
Rat | ||||||
Dog | cathepsin E | |||||
Publication Statistics
PubMed Score 247.31
PubMed score by year
PubTator Score 147.76
PubTator score by year
Related Publications
Text Mined References (42)
GeneRif Annotations (20)
Items per page:
0 of 0
PMID | Year | Title |
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