You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CTSC
Dipeptidyl peptidase 1

Protein Summary
Description
Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227266
  • ENSP00000227266
  • ENSG00000109861
  • ENST00000524463
  • ENSP00000432541
  • ENST00000529974
  • ENSP00000433539

Symbol
  • CPPI
  • JP
  • HMS
  • JPD
  • PLS
  • CPPI
  • DPP1
  • DPPI
  • PALS
  • DPP-I
  • PDON1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
disease perturbation
0.96
kinase perturbation
0.95
PubMedID
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.15   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 862.15   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 697
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (697)
CHEMBL390474
Rendered image for CHEMBL390474
CHEMBL230474
Rendered image for CHEMBL230474
CHEMBL567341
Rendered image for CHEMBL567341
CHEMBL567134
Rendered image for CHEMBL567134
CHEMBL230478
Rendered image for CHEMBL230478
CHEMBL390475
Rendered image for CHEMBL390475
CHEMBL1672434
Rendered image for CHEMBL1672434
CHEMBL514348
Rendered image for CHEMBL514348
Protein-Protein Interactions (246)
WFDC9
Tdark
Novelty:  3.44827586
p_int:  0.994723877
p_ni:  0.005276123
Score:  0.68
Data Source:  BioPlex,STRINGDB
CSTA
Tbio
Novelty:  0.00453121
p_int:  0.993962125
p_ni:  0.006037875
Score:  0.376
Data Source:  BioPlex,STRINGDB
DPP7
Tchem
Family:  Enzyme
Novelty:  0.00644738
Score:  0.963
Data Source:  STRINGDB
CTSG
Tchem
Family:  Enzyme
Novelty:  0.00102052
Score:  0.962
Data Source:  STRINGDB
PRTN3
Tchem
Family:  Enzyme
Novelty:  0.00022728
Score:  0.953
Data Source:  STRINGDB
ELANE
Tclin
Family:  Enzyme
Novelty:  0.00026112
Score:  0.951
Data Source:  STRINGDB
MCFD2
Tbio
Novelty:  0.0402944
Score:  0.95
Data Source:  STRINGDB
CTSA
Tchem
Family:  Enzyme
Novelty:  0.00170931
Score:  0.94
Data Source:  STRINGDB
LMAN1
Tbio
Novelty:  0.00595367
Score:  0.937
Data Source:  Reactome,STRINGDB
GUSB
Tchem
Family:  Enzyme
Novelty:  0.00053974
Score:  0.931
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
ER to Golgi Anterograde Transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
1
1
1
42.3
self reported educational attainment
1
1
1
38.2
gut microbiome measurement
1
1
0
6
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
1
42.3
self reported educational attainment
1
38.2
gut microbiome measurement
0
6
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cathepsin C
VGNC:3140
451469
Macaque
cathepsin C
705320
Mouse
MGI:109553
13032
Rat
RGD:2445
25423
Dog
cathepsin C
403458
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cathepsin C
Macaque
cathepsin C
Mouse
Rat
Dog
cathepsin C
Publication Statistics
PubMed Score 862.15
PubMed score by year
PubTator Score 307.64
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title