Tchem CTSB Cathepsin B

Protein Summary

Description

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P07858
• B3KQR5
• B3KRR5
• Q503A6
• Q96D87

Gene Name

• CTSB

Ensembl ID

• ENST00000345125
• ENSP00000342070
• ENSG00000164733
• ENST00000353047
• ENSP00000345672
• ENST00000453527
• ENSP00000409917
• ENST00000530640
• ENSP00000435105
• ENST00000531089
• ENSP00000433215
• ENST00000533455
• ENSP00000432244
• ENST00000534510
• ENSP00000434217

Symbol

• CPSB
• APPS
• CPSB
• RECEUP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.99
biological term	0.98
disease perturbation	0.98
cellular component	0.96

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Cathepsin B

Protein / ... / Protease Inhibitor / Cathepsin B

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Cathepsin B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4569.43   (req: < 5)

Gene RIFs: 254   (req: <= 3)

Antibodies: 578   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4569.43   (req: >= 5)

Gene RIFs: 254   (req: > 3)

Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 540

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1