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Tchem
CTRL
Chymotrypsin-like protease CTRL-1

Protein Summary
Description
This gene encodes a serine-type endopeptidase with chymotrypsin- and elastase-2-like activities. The gene encoding this zymogen is expressed specifically in the pancreas and likely functions as a digestive enzyme. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000574481
  • ENSP00000458537
  • ENSG00000141086

Symbol
  • CTRL1
  • CTRL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease
0.68
disease perturbation
0.68
virus perturbation
0.68
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1986.76   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1986.76   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (45)
PSME2
Tbio
Novelty:  0.02624268
p_int:  0.999998906
p_ni:  0.000001094
Score:  0.295
Data Source:  BioPlex,STRINGDB
PSME1
Tbio
Novelty:  0.01258149
p_int:  0.999982081
p_ni:  0.000017919
Score:  0.289
Data Source:  BioPlex,STRINGDB
ANKRD40
Tdark
Novelty:  1.06633958
p_int:  0.962545546
p_ni:  0.037454454
Score:  0.228
Data Source:  BioPlex,STRINGDB
CPA1
Tchem
Family:  Enzyme
Novelty:  0.00601525
Score:  0.961
Data Source:  STRINGDB
CPB1
Tchem
Family:  Enzyme
Novelty:  0.00108031
Score:  0.96
Data Source:  STRINGDB
CEL
Tchem
Family:  Enzyme
Novelty:  0.00156761
Score:  0.921
Data Source:  STRINGDB
CELA3B
Tbio
Family:  Enzyme
Novelty:  0.0039289
Score:  0.862
Data Source:  STRINGDB
CELA2A
Tbio
Family:  Enzyme
Novelty:  0.14098356
Score:  0.839
Data Source:  STRINGDB
CELA2B
Tdark
Family:  Enzyme
Novelty:  0.43122129
Score:  0.838
Data Source:  STRINGDB
PSMB10
Tchem
Family:  Enzyme
Novelty:  0.00567
Score:  0.803
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
18
22
38
10
99.5
apolipoprotein A 1 measurement
2
7
7
98.8
stem Cell Factor measurement
1
2
2
92.4
mean corpuscular volume
1
2
2
90.6
sleep duration
2
2
3
84.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
38
10
99.5
apolipoprotein A 1 measurement
7
98.8
stem Cell Factor measurement
2
92.4
mean corpuscular volume
2
90.6
sleep duration
3
84.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chymotrypsin like
VGNC:9027
454179
Macaque
chymotrypsin like
701625
Mouse
MGI:88558
109660
Rat
RGD:621501
117184
Dog
chymotrypsin like
VGNC:39707
611100
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chymotrypsin like
Macaque
chymotrypsin like
Mouse
Rat
Dog
chymotrypsin like
Publication Statistics
PubMed Score 1986.76
PubMed score by year
PubTator Score 131.15
PubTator score by year
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Related Publications
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PMID
Year
Title