Tchem CTRC Chymotrypsin-C

Protein Summary

Description

Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity. This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99895
• A8K082
• O00765
• Q9NUH5

Gene Name

• CTRC

Ensembl ID

• ENST00000375949
• ENSP00000365116
• ENSG00000162438

Symbol

• CLCR
• CLCR
• ELA4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.83
disease perturbation	0.74
gene perturbation	0.58
protein domain	0.58
tissue	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.74   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 146   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.74   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 39

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0