Protein Summary
Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity. This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
- ENST00000375949
- ENSP00000365116
- ENSG00000162438
- CLCR
- CLCR
- ELA4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.83 | ||
disease perturbation | 0.74 | ||
gene perturbation | 0.58 | ||
protein domain | 0.58 | ||
tissue | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 198.84 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 146 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 198.84 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 146 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 39
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (39)
Protein-Protein Interactions (42)
SUMF1
Family: Enzyme
Novelty: 0.00954537
p_int: 0.928459914
p_ni: 0.07150738
p_wrong: 0.000032706
Score: 0.39
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (4)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Metabolism of water-soluble vitamins and cofactors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Metabolism | ||||
Metabolism of vitamins and cofactors | ||||
Metabolism of water-soluble vitamins and cofactors | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 5 | 0 | 1.6 | 91.3 | |||||
urate measurement | 2 | 3 | 3 | 87.6 | |||||
creatinine measurement | 4 | 4 | 4 | 84.3 | |||||
glomerular filtration rate | 4 | 4 | 4 | 80.8 | |||||
body mass index | 2 | 2 | 2 | 49.4 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.6 | 91.3 | |||||
urate measurement | 3 | 87.6 | |||||
creatinine measurement | 4 | 84.3 | |||||
glomerular filtration rate | 4 | 80.8 | |||||
body mass index | 2 | 49.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | chymotrypsin C | VGNC:6116 | 739685 | |||||
Macaque | chymotrypsin C [Source:HGNC Symbol;Acc:HGNC:2523] | |||||||
Mouse | MGI:1923951 | 76701 | ||||||
Rat | RGD:1308379 | 362653 | ||||||
Horse | chymotrypsin C | VGNC:16946 | 100054423 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | chymotrypsin C | |||||
Macaque | chymotrypsin C [Source:HGNC Symbol;Acc:HGNC:2523] | |||||
Mouse | ||||||
Rat | ||||||
Horse | chymotrypsin C | |||||
Publication Statistics
PubMed Score 198.84
PubMed score by year
PubTator Score 141.30
PubTator score by year
Related Publications
Text Mined References (38)
GeneRif Annotations (30)
Items per page:
0 of 0
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