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Tbio
CTR9
RNA polymerase-associated protein CTR9 homolog

Protein Summary
Description
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361367
  • ENSP00000355013
  • ENSG00000198730

Symbol
  • KIAA0155
  • SH2BP1
  • TSBP
  • p150
  • SH2BP1
  • p150TSP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
drug perturbation
0.99
hub protein
0.92
kinase perturbation
0.88
histone modification site profile
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.8   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.8   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
PAF1
Tbio
Family:  Enzyme
Novelty:  0.00200047
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
CDC73
Tbio
Novelty:  0.00362973
p_int:  0.999999771
p_ni:  2.18e-7
p_wrong:  1.1e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999919357
p_ni:  0.000080643
Score:  0.437
Data Source:  BioPlex,STRINGDB
TULP2
Tbio
Family:  TF
Novelty:  0.20144336
p_int:  0.999846657
p_ni:  0.000153343
Score:  0.151
Data Source:  BioPlex,STRINGDB
MYLIP
Tbio
Family:  Enzyme
Novelty:  0.00836935
p_int:  0.998095374
p_ni:  0.001904625
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
APBA3
Tbio
Novelty:  0.05059532
p_int:  0.996677436
p_ni:  0.003322557
p_wrong:  7e-9
Data Source:  BioPlex
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.992246941
p_ni:  0.007753054
p_wrong:  5e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.987217525
p_ni:  0.012782458
p_wrong:  1.7e-8
Score:  0.213
Data Source:  BioPlex,STRINGDB
HASPIN
Tchem
Family:  Kinase
Novelty:  0.01574198
p_int:  0.980849764
p_ni:  0.019150234
p_wrong:  2e-9
Score:  0.33
Data Source:  BioPlex,STRINGDB
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.941382204
p_ni:  0.058617791
p_wrong:  5e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
migraine disorder
3
1
0
1.1
88.6
mean platelet volume
3
4
4
88.1
heel bone mineral density
2
1
2
69.1
blood protein measurement
1
1
1
62.1
cortical thickness
1
1
0
8.5
58.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
migraine disorder
0
1.1
88.6
mean platelet volume
4
88.1
heel bone mineral density
2
69.1
blood protein measurement
1
62.1
cortical thickness
0
8.5
58.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CTR9 homolog, Paf1/RNA polymerase II complex component
VGNC:6756
466442
Macaque
CTR9 homolog, Paf1/RNA polymerase II complex component
705748
Mouse
MGI:109345
22083
Rat
RGD:1311097
293184
Dog
CTR9 homolog, Paf1/RNA polymerase II complex component
VGNC:39706
100855495
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CTR9 homolog, Paf1/RNA polymerase II complex component
Macaque
CTR9 homolog, Paf1/RNA polymerase II complex component
Mouse
Rat
Dog
CTR9 homolog, Paf1/RNA polymerase II complex component
Publication Statistics
PubMed Score 34.80
PubMed score by year
PubTator Score 7.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title