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Tbio
CTPS2
CTP synthase 2

Protein Summary
Description
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides. The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359276
  • ENSP00000352222
  • ENSG00000047230
  • ENST00000380241
  • ENSP00000369590
  • ENST00000443824
  • ENSP00000401264
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
molecular function
0.86
disease perturbation
0.83
protein domain
0.73
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.7   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.7   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (215)
TIGD3
Tdark
Novelty:  1.23642174
p_int:  0.999973164
p_ni:  0.000026836
Score:  0.933
Data Source:  BioPlex,STRINGDB
CTPS1
Tbio
Family:  Enzyme
Novelty:  0.00911596
p_int:  0.999039139
p_ni:  0.000960859
p_wrong:  3e-9
Score:  0.988
Data Source:  BioPlex,STRINGDB
SUGP1
Tbio
Novelty:  0.00434166
p_int:  0.961447148
p_ni:  0.038552852
Score:  0.345
Data Source:  BioPlex,STRINGDB
POLR1B
Tbio
Family:  Enzyme
Novelty:  0.06955307
Score:  0.944
Data Source:  STRINGDB
GMPS
Tbio
Family:  Enzyme
Novelty:  0.00611806
Score:  0.926
Data Source:  STRINGDB
NME1
Tbio
Family:  Kinase
Novelty:  0.00103216
Score:  0.916
Data Source:  STRINGDB
NME4
Tbio
Family:  Kinase
Novelty:  0.03735196
Score:  0.912
Data Source:  STRINGDB
NME7
Tbio
Family:  Enzyme
Novelty:  0.08546782
Score:  0.91
Data Source:  STRINGDB
NME3
Tbio
Family:  Kinase
Novelty:  0.05947052
Score:  0.91
Data Source:  STRINGDB
NME6
Tbio
Family:  Kinase
Novelty:  0.12087274
Score:  0.91
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
1 – 3 of 3
UMPS
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
RRM2
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
RRM1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (11)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
71.9
prostate specific antigen measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
71.9
prostate specific antigen measurement
1
57.8
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CTP synthase 2
VGNC:1396
107971131
Macaque
CTP synthase 2
721014
Mouse
MGI:1933185
55936
Rat
RGD:1563369
619580
Dog
CTP synthase 2
VGNC:39705
480851
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CTP synthase 2
Macaque
CTP synthase 2
Mouse
Rat
Dog
CTP synthase 2
Publication Statistics
PubMed Score 16.70
PubMed score by year
PubTator Score 4.92
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title