Protein Summary
This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity. This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
- ENST00000372616
- ENSP00000361699
- ENSG00000171793
- ENST00000372621
- ENSP00000361704
- ENST00000649124
- ENSP00000497744
- ENST00000650070
- ENSP00000497602
- CTPS
- CTPS
- GATD5
- IMD24
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
virus perturbation | 1 | ||
interacting protein | 0.99 | ||
kinase perturbation | 0.99 | ||
hub protein | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 132.3 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 156 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 132.3 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 156 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (315)
CTPS2
Family: Enzyme
Novelty: 0.06147923
p_int: 0.999039139
p_ni: 0.000960859
p_wrong: 3e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
TIGD3
Novelty: 1.23642174
p_int: 0.997329056
p_ni: 0.002670944
Score: 0.888
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Downstream (3)
Pathways (11)
Reactome (3)
KEGG (2)
PathwayCommons (4)
UniProt (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Interconversion of nucleotide di- and triphosphates | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Interconversion of nucleotide di- and triphosphates | ||||
Metabolism | ||||
Metabolism of nucleotides | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (4)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 2 | 2 | 2 | 84.7 | |||||
heel bone mineral density | 3 | 2 | 3 | 83 | |||||
cognitive function measurement | 2 | 2 | 2 | 69.6 | |||||
appendicular lean mass | 2 | 1 | 2 | 69.4 | |||||
mathematical ability | 3 | 1 | 3 | 67.9 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 2 | 84.7 | |||||
heel bone mineral density | 3 | 83 | |||||
cognitive function measurement | 2 | 69.6 | |||||
appendicular lean mass | 2 | 69.4 | |||||
mathematical ability | 3 | 67.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CTP synthase 1 | VGNC:513 | 469296 | |||||
Macaque | CTP synthase 1 | 695498 | ||||||
Mouse | MGI:1858304 | 51797 | ||||||
Rat | RGD:1311060 | 313560 | ||||||
Dog | CTP synthase 1 | VGNC:39704 | 100687720 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CTP synthase 1 | |||||
Macaque | CTP synthase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | CTP synthase 1 | |||||
Publication Statistics
PubMed Score 132.30
PubMed score by year
PubTator Score 31.56
PubTator score by year
Related Publications
Text Mined References (34)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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