Protein Summary
May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
- ENST00000325551
- ENSP00000320434
- ENSG00000119326
- ENST00000374595
- ENSP00000363723
- ACRP
- CLLP
- alpha-CATU
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.95 | ||
transcription factor perturbation | 0.91 | ||
kinase perturbation | 0.88 | ||
PubMedID | 0.85 | ||
gene perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.59 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 133 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.59 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 133 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (51)
DMD
Novelty: 0.00025661
p_int: 0.999999994
p_ni: 1e-9
p_wrong: 6e-9
Score: 0.789
Data Source: BioPlex,STRINGDB
SNTG2
Novelty: 0.04056715
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.822
Data Source: BioPlex,STRINGDB
RPP25L
Family: Enzyme
Novelty: 1.39761189
p_int: 0.999995496
p_ni: 0.000004503
p_wrong: 1e-9
Data Source: BioPlex
RNF135
Family: Enzyme
Novelty: 0.05600338
p_int: 0.999733949
p_ni: 0.000265989
p_wrong: 6.2e-8
Score: 0.247
Data Source: BioPlex,STRINGDB
RHPN1
Novelty: 0.05722992
p_int: 0.999633524
p_ni: 0.00036647
p_wrong: 6e-9
Score: 0.175
Data Source: BioPlex,STRINGDB
SPERT
Novelty: 0.12255061
p_int: 0.99961393
p_ni: 0.000383085
p_wrong: 0.000002985
Score: 0.221
Data Source: BioPlex,STRINGDB
TAGAP
Family: Enzyme
Novelty: 0.04450409
p_int: 0.99164263
p_ni: 0.00798828
p_wrong: 0.00036909
Data Source: BioPlex
IFT20
Novelty: 0.03005088
p_int: 0.990510167
p_ni: 0.008651355
p_wrong: 0.000838478
Data Source: BioPlex
Nearest Tclin Targets
Pathways (22)
PathwayCommons (2)
WikiPathways (20)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: panther | Wnt signaling pathway | ||||
PathwayCommons: netpath | EGFR1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Wnt signaling pathway | ||||
EGFR1 | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 2 | 2 | 2 | 82 | |||||
glucose measurement | 2 | 2 | 2 | 78.2 | |||||
mathematical ability | 3 | 3 | 3 | 72.6 | |||||
body height | 1 | 1 | 1 | 57.8 | |||||
fasting blood glucose measurement | 1 | 1 | 1 | 56.6 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 2 | 82 | |||||
glucose measurement | 2 | 78.2 | |||||
mathematical ability | 3 | 72.6 | |||||
body height | 1 | 57.8 | |||||
fasting blood glucose measurement | 1 | 56.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | catenin alpha like 1 | VGNC:8810 | 464644 | |||||
Macaque | catenin alpha like 1 | 710389 | ||||||
Mouse | MGI:1859649 | 54366 | ||||||
Rat | RGD:1311434 | 298019 | ||||||
Dog | catenin alpha like 1 | VGNC:39699 | 610662 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | catenin alpha like 1 | |||||
Macaque | catenin alpha like 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | catenin alpha like 1 | |||||
Publication Statistics
PubMed Score 30.59
PubMed score by year
PubTator Score 9.86
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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