Tbio CTNNAL1 Alpha-catulin

Protein Summary

Description

May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).

Uniprot Accession IDs

• Q9UBT7
• B5BU47
• O76084
• Q53FQ2
• Q5JTQ7
• Q5JTQ8
• Q9Y401

Gene Name

• CTNNAL1

Ensembl ID

• ENST00000325551
• ENSP00000320434
• ENSG00000119326
• ENST00000374595
• ENSP00000363723

Symbol

• ACRP
• CLLP
• alpha-CATU

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.95
transcription factor perturbation	0.91
kinase perturbation	0.88
PubMedID	0.85
gene perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.84   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.84   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0