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Tbio
CTNNAL1
Alpha-catulin

Protein Summary
Description
May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325551
  • ENSP00000320434
  • ENSG00000119326
  • ENST00000374595
  • ENSP00000363723

Symbol
  • ACRP
  • CLLP
  • alpha-CATU
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
transcription factor perturbation
0.91
kinase perturbation
0.88
PubMedID
0.85
gene perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.59   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.59   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
DMD
Tclin
Novelty:  0.00025661
p_int:  0.999999994
p_ni:  1e-9
p_wrong:  6e-9
Score:  0.789
Data Source:  BioPlex,STRINGDB
SNTG2
Tbio
Novelty:  0.04056715
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.822
Data Source:  BioPlex,STRINGDB
SNTG1
Tbio
Novelty:  0.05608114
p_int:  0.999999955
p_ni:  4.5e-8
Data Source:  BioPlex
RPP25L
Tdark
Family:  Enzyme
Novelty:  1.39761189
p_int:  0.999995496
p_ni:  0.000004503
p_wrong:  1e-9
Data Source:  BioPlex
LY6D
Tbio
Novelty:  0.07032941
p_int:  0.999989393
p_ni:  0.000010607
Data Source:  BioPlex
RNF135
Tbio
Family:  Enzyme
Novelty:  0.05600338
p_int:  0.999733949
p_ni:  0.000265989
p_wrong:  6.2e-8
Score:  0.247
Data Source:  BioPlex,STRINGDB
RHPN1
Tbio
Novelty:  0.05722992
p_int:  0.999633524
p_ni:  0.00036647
p_wrong:  6e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
SPERT
Tbio
Novelty:  0.12255061
p_int:  0.99961393
p_ni:  0.000383085
p_wrong:  0.000002985
Score:  0.221
Data Source:  BioPlex,STRINGDB
TAGAP
Tbio
Family:  Enzyme
Novelty:  0.04450409
p_int:  0.99164263
p_ni:  0.00798828
p_wrong:  0.00036909
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.990510167
p_ni:  0.008651355
p_wrong:  0.000838478
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
82
glucose measurement
2
2
2
78.2
mathematical ability
3
3
3
72.6
body height
1
1
1
57.8
fasting blood glucose measurement
1
1
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
82
glucose measurement
2
78.2
mathematical ability
3
72.6
body height
1
57.8
fasting blood glucose measurement
1
56.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
catenin alpha like 1
VGNC:8810
464644
Macaque
catenin alpha like 1
710389
Mouse
MGI:1859649
54366
Rat
RGD:1311434
298019
Dog
catenin alpha like 1
VGNC:39699
610662
Species
Name
OMA
EggNOG
Inparanoid
Chimp
catenin alpha like 1
Macaque
catenin alpha like 1
Mouse
Rat
Dog
catenin alpha like 1
Publication Statistics
PubMed Score 30.59
PubMed score by year
PubTator Score 9.86
PubTator score by year
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Related Publications
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PMID
Year
Title