Tbio CTNNA3 Catenin alpha-3

Protein Summary

Description

May be involved in formation of stretch-resistant cell-cell adhesion complexes. This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q9UI47
• Q5VSR2
• Q6P056

Gene Name

• CTNNA3

Ensembl ID

• ENST00000433211
• ENSP00000389714
• ENSG00000183230

Symbol

• VR22
• ARVD13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
disease	0.72
cell type or tissue	0.7
transcription factor	0.66
transcription factor binding site profile	0.6

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Catenin Alpha-3

Protein / Cell Adhesion Molecule / Catenin Alpha-3

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Catenin Alpha-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.63   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.63   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (86)

Explore Interacting Targets

1 – 10 of 86

• See Interactions on String-DB

CDH3

Tbio

Novelty:  0.00295114

p_int:  0.999999981

p_ni:  6e-9

p_wrong:  1.4e-8

Score:  0.416

Data Source:  BioPlex,STRINGDB

CDH12

Tbio

Novelty:  0.05023568

p_int:  0.999999959

p_ni:  1e-9

p_wrong:  4e-8

Score:  0.363

Data Source:  BioPlex,STRINGDB

CDH1

Tbio

Novelty:  0.00010629

p_int:  0.999999802

p_ni:  4.4e-8

p_wrong:  1.54e-7

Score:  0.908

Data Source:  BioPlex,STRINGDB

APC

Tchem

Novelty:  0.00168376

p_int:  0.999999036

p_ni:  9.64e-7

Score:  0.36

Data Source:  BioPlex,STRINGDB

CDH24

Tbio

Novelty:  0.41415899

p_int:  0.999999025

p_ni:  5.8e-8

p_wrong:  9.17e-7

Score:  0.355

Data Source:  BioPlex,STRINGDB

BLZF1

Tbio

Novelty:  0.04344183

p_int:  0.999997697

p_ni:  0.000002303

Score:  0.185

Data Source:  BioPlex,STRINGDB

CDH10

Tbio

Novelty:  0.06137544

p_int:  0.999996276

p_ni:  9.44e-7

p_wrong:  0.00000278

Score:  0.437

Data Source:  BioPlex,STRINGDB

ARVCF

Tbio

Novelty:  0.03248592

p_int:  0.999989529

p_ni:  0.000010471

Score:  0.375

Data Source:  BioPlex,STRINGDB

PKP4

Tbio

Novelty:  0.03654703

p_int:  0.999989104

p_ni:  0.000010896

Score:  0.433

Data Source:  BioPlex,STRINGDB

CDH4

Tbio

Novelty:  0.01325411

p_int:  0.999877245

p_wrong:  0.000122755

Score:  0.443

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Downstream (2)

1 – 2 of 2

SRC

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  2

1: Adherens junction

2: Bacterial invasion of epithelial cells

ITGB2

Tclin

Family:  Other

KEGG Distance:  3

Common Pathways:  2

1: Hippo signaling pathway

2: Leukocyte transendothelial migration

Pathways (45)

KEGG (8)

PathwayCommons (1)

WikiPathways (36)

Find Similar Targets

Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Gastric cancer	148 targets	path:hsa05226
KEGG	Adherens junction	71 targets	path:hsa04520
KEGG	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	77 targets	path:hsa05412
KEGG	Hippo signaling pathway	154 targets	path:hsa04390
KEGG	Endometrial cancer	58 targets	path:hsa05213

Name	Explore in Pharos	Explore in Source
Gastric cancer	148 targets	path:hsa05226
Adherens junction	71 targets	path:hsa04520
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	77 targets	path:hsa05412
Hippo signaling pathway	154 targets	path:hsa04390
Endometrial cancer	58 targets	path:hsa05213

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (3)

Components (4)

Processes (4)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
beta-catenin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
cadherin binding	Traceable Author Statement (TAS)	UniProtKB
actin filament binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (20)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 20

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	3	7	7		89.9
neutrophil count	EFO_0004833	2	2	2		73.4
mathematical ability	EFO_0004875	1	2	2		70.4
mean platelet volume	EFO_0004584	2	2	2		64.8
wellbeing measurement	EFO_0007869	3	3	4		60.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 20

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	7		89.9
neutrophil count	EFO_0004833	2		73.4
mathematical ability	EFO_0004875	2		70.4
mean platelet volume	EFO_0004584	2		64.8
wellbeing measurement	EFO_0007869	4		60.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cardiomyopathy
Cell adhesion
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
cognitive function measurement
depressive symptom measurement
electrocardiography
essential tremor
glucose measurement
household income
intelligence
leukocyte count
mathematical ability

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
embryo phenotype
mortality/aging
muscle phenotype

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	catenin alpha 3 [Source:HGNC Symbol;Acc:HGNC:2511]
Mouse	catenin (cadherin associated protein), alpha 3	MGI:2661445	216033
Cow	catenin alpha 3	VGNC:27800	780777
Chicken	catenin alpha 3	CGNC:2051	423648
C. elegans	Alpha-catenin-like protein hmp-1		179624

Species	Name	OMA	EggNOG	Inparanoid
Macaque	catenin alpha 3 [Source:HGNC Symbol;Acc:HGNC:2511]
Mouse	catenin (cadherin associated protein), alpha 3
Cow	catenin alpha 3
Chicken	catenin alpha 3
C. elegans	Alpha-catenin-like protein hmp-1

Publication Statistics

PubMed Score 63.63

PubMed score by year

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PubTator Score 33.91

PubTator score by year

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Related Publications

Text Mined References (57)

GeneRif Annotations (41)

Items per page:

10

0 of 0

PMID	Year	Title