Tbio CTNNA3 Catenin alpha-3

Protein Summary

Description

May be involved in formation of stretch-resistant cell-cell adhesion complexes. This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q9UI47
• Q5VSR2
• Q6P056

Gene Name

• CTNNA3

Ensembl ID

• ENST00000433211
• ENSP00000389714
• ENSG00000183230

Symbol

• VR22
• ARVD13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
disease	0.72
cell type or tissue	0.7
transcription factor	0.66
transcription factor binding site profile	0.6

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Catenin Alpha-3

Protein / Cell Adhesion Molecule / Catenin Alpha-3

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Catenin Alpha-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.78   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 155   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.78   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0