Protein Summary
May be involved in formation of stretch-resistant cell-cell adhesion complexes. This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
- ENST00000433211
- ENSP00000389714
- ENSG00000183230
- VR22
- ARVD13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
trait | 1 | ||
disease | 0.72 | ||
cell type or tissue | 0.7 | ||
transcription factor | 0.66 | ||
transcription factor binding site profile | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.63 (req: < 5)
Gene RIFs: 41 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 63.63 (req: >= 5)
Gene RIFs: 41 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (86)
CDH3
Novelty: 0.00295114
p_int: 0.999999981
p_ni: 6e-9
p_wrong: 1.4e-8
Score: 0.416
Data Source: BioPlex,STRINGDB
CDH12
Novelty: 0.05023568
p_int: 0.999999959
p_ni: 1e-9
p_wrong: 4e-8
Score: 0.363
Data Source: BioPlex,STRINGDB
CDH1
Novelty: 0.00010629
p_int: 0.999999802
p_ni: 4.4e-8
p_wrong: 1.54e-7
Score: 0.908
Data Source: BioPlex,STRINGDB
APC
Novelty: 0.00168376
p_int: 0.999999036
p_ni: 9.64e-7
Score: 0.36
Data Source: BioPlex,STRINGDB
CDH24
Novelty: 0.41415899
p_int: 0.999999025
p_ni: 5.8e-8
p_wrong: 9.17e-7
Score: 0.355
Data Source: BioPlex,STRINGDB
BLZF1
Novelty: 0.04344183
p_int: 0.999997697
p_ni: 0.000002303
Score: 0.185
Data Source: BioPlex,STRINGDB
CDH10
Novelty: 0.06137544
p_int: 0.999996276
p_ni: 9.44e-7
p_wrong: 0.00000278
Score: 0.437
Data Source: BioPlex,STRINGDB
ARVCF
Novelty: 0.03248592
p_int: 0.999989529
p_ni: 0.000010471
Score: 0.375
Data Source: BioPlex,STRINGDB
PKP4
Novelty: 0.03654703
p_int: 0.999989104
p_ni: 0.000010896
Score: 0.433
Data Source: BioPlex,STRINGDB
CDH4
Novelty: 0.01325411
p_int: 0.999877245
p_wrong: 0.000122755
Score: 0.443
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (45)
KEGG (8)
PathwayCommons (1)
WikiPathways (36)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Gastric cancer | ||||
KEGG | Adherens junction | ||||
KEGG | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ||||
KEGG | Hippo signaling pathway | ||||
KEGG | Endometrial cancer | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Gastric cancer | ||||
Adherens junction | ||||
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ||||
Hippo signaling pathway | ||||
Endometrial cancer | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (3)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 3 | 7 | 7 | 89.9 | |||||
neutrophil count | 2 | 2 | 2 | 73.4 | |||||
mathematical ability | 1 | 2 | 2 | 70.4 | |||||
mean platelet volume | 2 | 2 | 2 | 64.8 | |||||
wellbeing measurement | 3 | 3 | 4 | 60.2 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
self reported educational attainment | 7 | 89.9 | |||||
neutrophil count | 2 | 73.4 | |||||
mathematical ability | 2 | 70.4 | |||||
mean platelet volume | 2 | 64.8 | |||||
wellbeing measurement | 4 | 60.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | catenin alpha 3 [Source:HGNC Symbol;Acc:HGNC:2511] | |||||||
Mouse | MGI:2661445 | 216033 | ||||||
Cow | catenin alpha 3 | VGNC:27800 | 780777 | |||||
Chicken | catenin alpha 3 | CGNC:2051 | 423648 | |||||
C. elegans | 179624 | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | catenin alpha 3 [Source:HGNC Symbol;Acc:HGNC:2511] | |||||
Mouse | ||||||
Cow | catenin alpha 3 | |||||
Chicken | catenin alpha 3 | |||||
C. elegans | ||||||
Publication Statistics
PubMed Score 63.63
PubMed score by year
PubTator Score 33.91
PubTator score by year
Related Publications
Text Mined References (57)
GeneRif Annotations (41)
Items per page:
0 of 0
PMID | Year | Title |
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