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Tbio
CTF1
Cardiotrophin-1

Protein Summary
Description
Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279804
  • ENSP00000279804
  • ENSG00000150281
  • ENST00000395019
  • ENSP00000378465

Symbol
  • CT1
  • CT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.69
disease perturbation
0.68
transcription factor
0.67
transcription factor binding site profile
0.62
biological process
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.27   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 467   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.27   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 467   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
LIFR
Tbio
Novelty:  0.00514085
Score:  0.982
Data Source:  Reactome,STRINGDB
LIF
Tbio
Novelty:  0.00094373
Score:  0.979
Data Source:  STRINGDB
IL6ST
Tclin
Novelty:  0.01026472
Score:  0.962
Data Source:  Reactome,STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.945
Data Source:  Reactome,STRINGDB
HBEGF
Tbio
Novelty:  0.00105355
Score:  0.941
Data Source:  STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.94
Data Source:  Reactome,STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
Score:  0.934
Data Source:  STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.933
Data Source:  STRINGDB
ALOX15B
Tchem
Family:  Enzyme
Novelty:  0.01578108
Score:  0.905
Data Source:  STRINGDB
SHC1
Tchem
Novelty:  0.00083615
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
1 – 5 of 17
EPOR
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL4R
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL5RA
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
IL6ST
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
CSF3R
Tclin
Family:  Other
KEGG Distance:  1
Common Pathways:  2
Pathways (232)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
Immune System
Reactome
Interleukin-6 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
IL-6-type cytokine receptor ligand interactions
Immune System
Interleukin-6 family signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.2
83.1
mean reticulocyte volume
1
1
1
82.8
mean corpuscular volume
1
1
1
82.2
serum non-albumin protein measurement
1
1
1
71.3
eosinophil count
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
83.1
mean reticulocyte volume
1
82.8
mean corpuscular volume
1
82.2
serum non-albumin protein measurement
1
71.3
eosinophil count
1
62.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cardiotrophin 1
VGNC:5747
467955
Mouse
MGI:105115
13019
Rat
RGD:2442
29201
Dog
cardiotrophin 1
VGNC:54015
403821
Horse
cardiotrophin 1
VGNC:51121
100065094
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cardiotrophin 1
Mouse
Rat
Dog
cardiotrophin 1
Horse
cardiotrophin 1
Publication Statistics
PubMed Score 313.27
PubMed score by year
PubTator Score 543.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title