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Tbio
CTDSP2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

Protein Summary
Description
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398073
  • ENSP00000381148
  • ENSG00000175215

Symbol
  • NIF2
  • OS4
  • SCP2
  • OS4
  • PSR2
  • SCP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
virus perturbation
0.99
transcription factor perturbation
0.96
microRNA
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.52   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.52   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
CDCA3
Tbio
Novelty:  0.05136899
p_int:  0.999999977
p_ni:  2.3e-8
Score:  0.723
Data Source:  BioPlex,STRINGDB
CTDSP1
Tchem
Family:  Enzyme
Novelty:  0.0231786
p_int:  0.999978429
p_wrong:  0.000021571
Score:  0.545
Data Source:  BioPlex,STRINGDB
CWC22
Tbio
Novelty:  0.027689
p_int:  0.999938738
p_ni:  0.000061262
Score:  0.236
Data Source:  BioPlex,STRINGDB
PRR14
Tbio
Novelty:  0.22401806
p_int:  0.99986232
p_ni:  0.0001294
p_wrong:  0.00000828
Score:  0.177
Data Source:  BioPlex,STRINGDB
ENDOD1
Tdark
Family:  Enzyme
Novelty:  0.26430864
p_int:  0.999610022
p_ni:  0.000389978
Score:  0.196
Data Source:  BioPlex,STRINGDB
MAP7D1
Tdark
Novelty:  0.43190333
p_int:  0.999210842
p_ni:  0.000789158
Score:  0.215
Data Source:  BioPlex,STRINGDB
ZMYM6
Tbio
Novelty:  0.4933879
p_int:  0.998475704
p_ni:  0.001524296
Data Source:  BioPlex
INTS6
Tbio
Novelty:  0.02680242
p_int:  0.997549703
p_ni:  0.002450295
p_wrong:  2e-9
Score:  0.195
Data Source:  BioPlex,STRINGDB
TBC1D4
Tbio
Novelty:  0.00549202
p_int:  0.991316007
p_ni:  0.008683993
Score:  0.16
Data Source:  BioPlex,STRINGDB
ZC3H3
Tbio
Novelty:  0.26894046
p_int:  0.988512208
p_ni:  0.011487664
p_wrong:  1.28e-7
Score:  0.155
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
3
3
0
1.1
96.7
intelligence
2
2
1
6.8
67.5
urate measurement
1
1
1
62.1
heel bone mineral density
1
1
1
50.9
high density lipoprotein cholesterol measurement
1
1
1
49.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
0
1.1
96.7
intelligence
1
6.8
67.5
urate measurement
1
62.1
heel bone mineral density
1
50.9
high density lipoprotein cholesterol measurement
1
49.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CTD small phosphatase 2
VGNC:5350
746009
Macaque
CTD small phosphatase 2
715956
Mouse
MGI:1098748
52468
Dog
CTD small phosphatase 2
VGNC:39694
481135
Horse
CTD small phosphatase 2
VGNC:16932
100053912
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CTD small phosphatase 2
Macaque
CTD small phosphatase 2
Mouse
Dog
CTD small phosphatase 2
Horse
CTD small phosphatase 2
Publication Statistics
PubMed Score 133.52
PubMed score by year
PubTator Score 8.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title