Tchem CTDSP1 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Protein Summary

Description

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q9GZU7
• C9IYG0
• Q7Z5Q3
• Q7Z5Q4

Gene Name

• CTDSP1

Ensembl ID

• ENST00000273062
• ENSP00000273062
• ENSG00000144579
• ENST00000443891
• ENSP00000392248

Symbol

• NIF3
• NLIIF
• SCP1
• NIF3
• SCP1
• NLIIF
• NLI-IF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.92
hub protein	0.71
transcription factor	0.71
histone modification site profile	0.64
biological process	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.83   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 351   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.83   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0