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Tbio
CTC1
CST complex subunit CTC1

Protein Summary
Description
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315684
  • ENSP00000313759
  • ENSG00000178971
  • ENST00000449476
  • ENSP00000396018

Symbol
  • C17orf68
  • CRMCC
  • AAF132
  • AAF-132
  • C17orf68
  • tmp494178
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor binding site profile
0.77
microRNA
0.73
biological process
0.68
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.09   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.09   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
STN1
Tbio
Novelty:  0.01309587
p_int:  0.999999215
p_ni:  7.85e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
GMNN
Tbio
Novelty:  0.00436572
p_int:  0.999946442
p_ni:  0.000053558
Score:  0.165
Data Source:  BioPlex,STRINGDB
CNPY2
Tbio
Novelty:  0.090889
p_int:  0.99991322
p_ni:  0.00008678
Score:  0.588
Data Source:  BioPlex,STRINGDB
TFAP4
Tbio
Family:  TF
Novelty:  0.03155887
p_int:  0.999200163
p_ni:  0.000799493
p_wrong:  3.45e-7
Score:  0.305
Data Source:  BioPlex,STRINGDB
TEN1
Tbio
Novelty:  0.02194283
p_int:  0.998481114
p_ni:  0.001518711
p_wrong:  1.74e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
CDC34
Tbio
Novelty:  0.00650407
p_int:  0.994328231
p_ni:  0.005671574
p_wrong:  1.95e-7
Data Source:  BioPlex
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.991312557
p_ni:  0.008683079
p_wrong:  0.000004364
Data Source:  BioPlex
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.99054315
p_ni:  0.009456654
p_wrong:  1.96e-7
Data Source:  BioPlex
KCTD17
Tbio
Novelty:  0.12105733
p_int:  0.988951275
p_ni:  0.01096214
p_wrong:  0.000086584
Data Source:  BioPlex
NELL2
Tbio
Family:  Enzyme
Novelty:  0.03760438
p_int:  0.988541216
p_ni:  0.011375741
p_wrong:  0.000083043
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
3
4
94.2
chronotype measurement
2
3
2
1.1
88.6
hemoglobin measurement
2
2
2
84.7
total cholesterol measurement
2
2
2
77.4
mean corpuscular volume
1
1
1
72.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
4
94.2
chronotype measurement
2
1.1
88.6
hemoglobin measurement
2
84.7
total cholesterol measurement
2
77.4
mean corpuscular volume
1
72.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CST telomere replication complex component 1
VGNC:9418
455094
Macaque
CST telomere replication complex component 1
717075
Mouse
MGI:1916214
68964
Rat
RGD:1563106
303238
Dog
CST telomere replication complex component 1
VGNC:39689
479493
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CST telomere replication complex component 1
Macaque
CST telomere replication complex component 1
Mouse
Rat
Dog
CST telomere replication complex component 1
Publication Statistics
PubMed Score 90.09
PubMed score by year
PubTator Score 38.22
PubTator score by year
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Related Publications
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PMID
Year
Title