Tchem CTBP2 C-terminal-binding protein 2

Protein Summary

Description

Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). Isoform 2 probably acts as a scaffold for specialized synapses. This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• P56545
• A8K2X5
• D3DRF5
• O43449
• Q5SQP7
• Q69YI3
• Q86SV0
• Q8IY44
• Q9H2T8
• CtBP2

Gene Name

• CTBP2

Ensembl ID

• ENST00000309035
• ENSP00000311825
• ENSG00000175029
• ENST00000334808
• ENSP00000357816
• ENST00000337195
• ENSP00000338615
• ENST00000411419
• ENSP00000410474
• ENST00000494626
• ENSP00000436285
• ENST00000531469
• ENSP00000434630

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
PubMedID	0.97
disease perturbation	0.96
molecular function	0.88
transcription factor binding site profile	0.85

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / C-terminal-binding Protein 2

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / C-terminal-binding Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.54   (req: < 5)

Gene RIFs: 75   (req: <= 3)

Antibodies: 330   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.54   (req: >= 5)

Gene RIFs: 75   (req: > 3)

Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0