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Tbio
CSTL1
Cystatin-like 1

Protein Summary
Description
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located at the telomeric end of the cystatin locus and encodes a type 2 cystatin-like protein. The specific function of this protein has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246020
  • ENSP00000246020
  • ENSG00000125823
  • ENST00000347397
  • ENSP00000344907

Symbol
  • CTES1
  • RCET11
  • dJ322G13.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.58
tissue sample
0.39
cell type or tissue
0.37
tissue
0.33
transcription factor
0.33


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.58   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.58   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
KDM8
Tbio
Family:  Epigenetic
Novelty:  0.03368031
p_int:  0.999999993
p_ni:  6e-9
Data Source:  BioPlex
GOLIM4
Tbio
Novelty:  0.01923513
p_int:  0.999972293
p_ni:  0.000027706
p_wrong:  1e-9
Data Source:  BioPlex
SUSD5
Tdark
Novelty:  1.0992718
p_int:  0.999912762
p_ni:  0.000002801
p_wrong:  0.000084436
Data Source:  BioPlex
NUCB1
Tchem
Novelty:  0.0040312
p_int:  0.999481254
p_ni:  0.000518746
Data Source:  BioPlex
CPE
Tbio
Family:  Enzyme
Novelty:  0.00197792
p_int:  0.998013322
p_ni:  0.001984739
p_wrong:  0.000001939
Data Source:  BioPlex
NMU
Tbio
Novelty:  0.00326109
p_int:  0.996801619
p_ni:  0.000567522
p_wrong:  0.002630859
Data Source:  BioPlex
TMEM131
Tdark
Novelty:  0.02152783
p_int:  0.996026103
p_ni:  0.003973897
Data Source:  BioPlex
APOE
Tbio
Novelty:  0.00005049
p_int:  0.995165683
p_ni:  0.000299998
p_wrong:  0.004534319
Data Source:  BioPlex
PPTC7
Tdark
Family:  Enzyme
Novelty:  0.36770849
p_int:  0.99409755
p_ni:  0.005556945
p_wrong:  0.000345504
Data Source:  BioPlex
LOXL2
Tchem
Family:  Enzyme
Novelty:  0.00599536
p_int:  0.992981367
p_ni:  0.007016735
p_wrong:  0.000001897
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.7
3.4
age at onset
1
1
0
5.7
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.7
3.4
age at onset
0
5.7
3.4
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2652834
228756
Rat
RGD:1307417
296220
Dog
cystatin like 1
VGNC:39685
606837
Horse
cystatin like 1
VGNC:16923
100059008
Cow
cystatin like 1
VGNC:27784
523331
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cystatin like 1
Horse
cystatin like 1
Cow
cystatin like 1
Publication Statistics
PubMed Score 6.58
PubMed score by year
PubTator Score 1.33
PubTator score by year
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Related Publications
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PMID
Year
Title