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Tbio
CSTF2
Cleavage stimulation factor subunit 2

Protein Summary
Description
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity). This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372972
  • ENSP00000362063
  • ENSG00000101811

Symbol
  • CstF-64
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
kinase perturbation
0.84
disease perturbation
0.83
interacting protein
0.69
transcription factor binding site profile
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.15   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.15   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (296)
CSTF2T
Tbio
Novelty:  0.11811814
p_int:  0.999999961
p_ni:  3.9e-8
Score:  0.988
Data Source:  BioPlex,STRINGDB
CPSF4
Tbio
Novelty:  0.00206207
p_int:  0.837264735
p_ni:  0.162735262
p_wrong:  3e-9
Score:  0.99
Data Source:  BioPlex,STRINGDB
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.815801947
p_ni:  0.184198053
Data Source:  BioPlex
CPEB1
Tbio
Novelty:  0.00444378
p_int:  0.791172938
p_ni:  0.208827061
Score:  0.89
Data Source:  BioPlex,STRINGDB
CSTF3
Tbio
Novelty:  0.05260909
Score:  0.999
Data Source:  Reactome,STRINGDB
CPSF3
Tchem
Novelty:  0.01880576
Score:  0.998
Data Source:  STRINGDB
SYMPK
Tbio
Novelty:  0.01773552
Score:  0.998
Data Source:  STRINGDB
CSTF1
Tbio
Novelty:  0.08711712
Score:  0.998
Data Source:  Reactome,STRINGDB
CPSF2
Tbio
Novelty:  0.0510853
Score:  0.998
Data Source:  STRINGDB
CPSF1
Tbio
Novelty:  0.04396897
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cleavage stimulation factor subunit 2
VGNC:10175
473699
Macaque
cleavage stimulation factor subunit 2
701235
Mouse
MGI:1343054
108062
Rat
RGD:1596566
683927
Dog
cleavage stimulation factor subunit 2
VGNC:39683
492015
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cleavage stimulation factor subunit 2
Macaque
cleavage stimulation factor subunit 2
Mouse
Rat
Dog
cleavage stimulation factor subunit 2
Publication Statistics
PubMed Score 75.15
PubMed score by year
PubTator Score 38.68
PubTator score by year
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Related Publications
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PMID
Year
Title