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Tbio
CSTB
Cystatin-B

Protein Summary
Description
This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter regio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291568
  • ENSP00000291568
  • ENSG00000160213

Symbol
  • CST6
  • STFB
  • PME
  • ULD
  • CST6
  • EPM1
  • STFB
  • CPI-B
  • EPM1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
virus perturbation
0.97
transcription factor perturbation
0.96
interacting protein
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 410.51   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 713   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 410.51   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 713   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
CTSH
Tchem
Family:  Enzyme
Novelty:  0.00336694
Score:  0.98
Data Source:  STRINGDB
CST3
Tbio
Novelty:  0.00021856
Score:  0.979
Data Source:  STRINGDB
CTSD
Tchem
Family:  Enzyme
Novelty:  0.00029823
Score:  0.964
Data Source:  STRINGDB
B2M
Tbio
Novelty:  0.00011248
Score:  0.941
Data Source:  STRINGDB
CTSS
Tchem
Family:  Enzyme
Novelty:  0.00786042
Score:  0.937
Data Source:  STRINGDB
LTF
Tbio
Novelty:  0.00114254
Score:  0.92
Data Source:  STRINGDB
LYZ
Tbio
Family:  Enzyme
Novelty:  0.00151342
Score:  0.92
Data Source:  STRINGDB
SPTAN1
Tbio
Novelty:  0.00286901
Score:  0.918
Data Source:  STRINGDB
HP
Tbio
Novelty:  0.00016649
Score:  0.912
Data Source:  STRINGDB
TIMP2
Tbio
Family:  Enzyme
Novelty:  0.00064016
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
2
2
92.6
cystatin B measurement
2
1
2
60.1
homocysteine measurement
1
1
1
23.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
92.6
cystatin B measurement
2
60.1
homocysteine measurement
1
23.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cystatin B
713504
Mouse
MGI:109514
13014
Rat
RGD:2435
25308
Dog
cystatin B [Source:HGNC Symbol;Acc:HGNC:2482]
Horse
cystatin-B
100050760
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cystatin B
Mouse
Rat
Dog
cystatin B [Source:HGNC Symbol;Acc:HGNC:2482]
Horse
cystatin-B
Publication Statistics
PubMed Score 410.51
PubMed score by year
PubTator Score 413.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title