Tbio CSTA Cystatin-A

Protein Summary

Description

This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P01040
• Q6IB90

Gene Name

• CSTA

Ensembl ID

• ENST00000264474
• ENSP00000264474
• ENSG00000121552

Symbol

• STF1
• STFA
• AREI
• PSS4
• STF1
• STFA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
gene perturbation	0.98
virus perturbation	0.92
interacting protein	0.86
small molecule perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Cysteine Protease Inhibitor / Cystatin-a

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Cysteine Protease Inhibitor / Cystatin-a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.36   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 454   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.36   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 454   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (105)

Explore Interacting Targets

1 – 10 of 105

• See Interactions on String-DB

CTSH

Tchem

Family:  Enzyme

Novelty:  0.00336694

p_int:  0.999995747

p_ni:  0.000004253

Score:  0.776

Data Source:  BioPlex,STRINGDB

CTSL

Tclin

Family:  Enzyme

Novelty:  0.00058727

p_int:  0.999940537

p_ni:  0.00005939

p_wrong:  7.3e-8

Score:  0.952

Data Source:  BioPlex,STRINGDB

CTSF

Tchem

Family:  Enzyme

Novelty:  0.01359417

p_int:  0.999485556

p_ni:  0.000501783

p_wrong:  0.000012662

Score:  0.403

Data Source:  BioPlex,STRINGDB

CTSO

Tbio

Family:  Enzyme

Novelty:  0.09963965

p_int:  0.998751014

p_ni:  0.000004231

p_wrong:  0.001244755

Score:  0.302

Data Source:  BioPlex,STRINGDB

TGFBRAP1

Tbio

Novelty:  0.05996919

p_int:  0.996238142

p_ni:  0.003761833

p_wrong:  2.5e-8

Data Source:  BioPlex

CTSC

Tchem

Family:  Enzyme

Novelty:  0.00119917

p_int:  0.993962125

p_ni:  0.006037875

Score:  0.376

Data Source:  BioPlex,STRINGDB

CTSV

Tchem

Family:  Enzyme

Novelty:  0.00916301

p_int:  0.993916843

p_ni:  0.005965065

p_wrong:  0.000118092

Score:  0.861

Data Source:  BioPlex,STRINGDB

CTSB

Tchem

Family:  Enzyme

Novelty:  0.00026238

p_int:  0.969600772

p_ni:  0.030399228

Score:  0.977

Data Source:  BioPlex,STRINGDB

VPS11

Tbio

Novelty:  0.00496411

p_int:  0.963289208

p_ni:  0.03671079

p_wrong:  1e-9

Data Source:  BioPlex

ZIC1

Tbio

Family:  TF

Novelty:  0.00491601

p_int:  0.799875895

p_ni:  0.200124105

Score:  0.211

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Formation of the cornified envelope	75 targets	R-HSA-6809371
Reactome	Keratinization	217 targets	R-HSA-6805567

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Formation of the cornified envelope	75 targets	R-HSA-6809371
Keratinization	217 targets	R-HSA-6805567

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (4)

Components (5)

Processes (6)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
cysteine-type endopeptidase inhibitor activity	Inferred from Direct Assay (IDA)	UniProtKB
protein binding, bridging	Inferred from Direct Assay (IDA)	UniProtKB
structural molecule activity	Inferred from Direct Assay (IDA)	UniProtKB
protease binding	Inferred from Physical Interaction (IPI)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
calcium measurement	EFO_0004838	4	13	13		99.2
eosinophil count	EFO_0004842	2	2	2		71.4
eosinophil percentage of leukocytes	EFO_0007991	1	1	1		64.4
mean corpuscular volume	EFO_0004526	1	1	1		59.6
type II diabetes mellitus	EFO_0001360	4	3	2	1	53.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
calcium measurement	EFO_0004838	13		99.2
eosinophil count	EFO_0004842	2		71.4
eosinophil percentage of leukocytes	EFO_0007991	1		64.4
mean corpuscular volume	EFO_0004526	1		59.6
type II diabetes mellitus	EFO_0001360	2	1	53.7

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Cell adhesion
Complete proteome
Cytoplasm
Direct protein sequencing
Ichthyosis
Polymorphism
Protease inhibitor
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein B measurement
calcium measurement
diastolic blood pressure
eosinophil count
eosinophil percentage of leukocytes
low density lipoprotein cholesterol measurement
mathematical ability
mean corpuscular volume
metabolite measurement
nephrolithiasis

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cystatin A	VGNC:6196	746075
Macaque	cystatin A		714547
Mouse	stefin A1	MGI:106198	20861
Mouse	predicted gene 5416	MGI:3644688	408196
Rat	rCG64393-like	RGD:2323715	100362978

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cystatin A
Macaque	cystatin A
Mouse	stefin A1
Mouse	predicted gene 5416
Rat	rCG64393-like

Publication Statistics

PubMed Score 227.36

PubMed score by year

Reset Zoom

PubTator Score 137.38

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (71)

GeneRif Annotations (34)

Items per page:

10

0 of 0

PMID	Year	Title