Protein Summary
This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]
- ENST00000264474
- ENSP00000264474
- ENSG00000121552
- STF1
- STFA
- AREI
- PSS4
- STF1
- STFA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein complex | 1 | ||
gene perturbation | 0.98 | ||
virus perturbation | 0.92 | ||
interacting protein | 0.86 | ||
small molecule perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.36 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 454 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.36 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 454 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (105)
CTSH
Family: Enzyme
Novelty: 0.00336694
p_int: 0.999995747
p_ni: 0.000004253
Score: 0.776
Data Source: BioPlex,STRINGDB
CTSL
Family: Enzyme
Novelty: 0.00058727
p_int: 0.999940537
p_ni: 0.00005939
p_wrong: 7.3e-8
Score: 0.952
Data Source: BioPlex,STRINGDB
CTSF
Family: Enzyme
Novelty: 0.01359417
p_int: 0.999485556
p_ni: 0.000501783
p_wrong: 0.000012662
Score: 0.403
Data Source: BioPlex,STRINGDB
CTSO
Family: Enzyme
Novelty: 0.09963965
p_int: 0.998751014
p_ni: 0.000004231
p_wrong: 0.001244755
Score: 0.302
Data Source: BioPlex,STRINGDB
TGFBRAP1
Novelty: 0.05996919
p_int: 0.996238142
p_ni: 0.003761833
p_wrong: 2.5e-8
Data Source: BioPlex
CTSC
Family: Enzyme
Novelty: 0.00119917
p_int: 0.993962125
p_ni: 0.006037875
Score: 0.376
Data Source: BioPlex,STRINGDB
CTSV
Family: Enzyme
Novelty: 0.00916301
p_int: 0.993916843
p_ni: 0.005965065
p_wrong: 0.000118092
Score: 0.861
Data Source: BioPlex,STRINGDB
CTSB
Family: Enzyme
Novelty: 0.00026238
p_int: 0.969600772
p_ni: 0.030399228
Score: 0.977
Data Source: BioPlex,STRINGDB
ZIC1
Family: TF
Novelty: 0.00491601
p_int: 0.799875895
p_ni: 0.200124105
Score: 0.211
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (4)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
calcium measurement | 4 | 13 | 13 | 99.2 | |||||
eosinophil count | 2 | 2 | 2 | 71.4 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 64.4 | |||||
mean corpuscular volume | 1 | 1 | 1 | 59.6 | |||||
4 | 3 | 2 | 1 | 53.7 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
calcium measurement | 13 | 99.2 | |||||
eosinophil count | 2 | 71.4 | |||||
eosinophil percentage of leukocytes | 1 | 64.4 | |||||
mean corpuscular volume | 1 | 59.6 | |||||
2 | 1 | 53.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cystatin A | VGNC:6196 | 746075 | |||||
Macaque | cystatin A | 714547 | ||||||
Mouse | MGI:106198 | 20861 | ||||||
Mouse | MGI:3644688 | 408196 | ||||||
Rat | RGD:2323715 | 100362978 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cystatin A | |||||
Macaque | cystatin A | |||||
Mouse | ||||||
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 227.36
PubMed score by year
PubTator Score 137.38
PubTator score by year
Related Publications
Text Mined References (71)
GeneRif Annotations (34)
Items per page:
0 of 0
PMID | Year | Title |
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