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Tdark
CST9L
Cystatin-9-like

Protein Summary
Description
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to mouse cystatin 9. Based on its testis-specific expression, it is likely to have a role in tissue reorganization during early testis development. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376979
  • ENSP00000366178
  • ENSG00000101435

Symbol
  • CTES7B
  • CTES7B
  • bA218C14.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
cell line
0.58
cell type or tissue
0.58
protein domain
0.41
molecular function
0.38


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.63   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.63   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
SEMA4D
Tbio
Novelty:  0.0043592
p_int:  0.999999047
p_ni:  9.53e-7
Data Source:  BioPlex
EPHA5
Tchem
Family:  Kinase
Novelty:  0.01143252
p_int:  0.999606149
p_ni:  0.000004429
p_wrong:  0.000389423
Data Source:  BioPlex
CEMIP2
Tbio
Novelty:  0.04698236
p_int:  0.997862834
p_ni:  0.002137147
p_wrong:  1.8e-8
Data Source:  BioPlex
SUSD1
Tdark
Novelty:  0.54249826
p_int:  0.996908286
p_ni:  0.002769349
p_wrong:  0.000322365
Data Source:  BioPlex
LAMA5
Tbio
Novelty:  0.02247145
p_int:  0.996033158
p_ni:  0.003966842
Data Source:  BioPlex
FKBP7
Tbio
Family:  Enzyme
Novelty:  0.00572565
p_int:  0.990580808
p_ni:  0.009419192
Data Source:  BioPlex
ARSK
Tbio
Family:  Enzyme
Novelty:  0.11486213
p_int:  0.989399466
p_ni:  0.010600534
Data Source:  BioPlex
QSOX1
Tbio
Family:  Enzyme
Novelty:  0.02152583
p_int:  0.988964726
p_ni:  0.010397742
p_wrong:  0.000637531
Data Source:  BioPlex
EOGT
Tbio
Family:  Enzyme
Novelty:  0.08290891
p_int:  0.987005991
p_ni:  0.012993166
p_wrong:  8.43e-7
Data Source:  BioPlex
SEMA6A
Tbio
Novelty:  0.00624456
p_int:  0.986490729
p_ni:  0.013505923
p_wrong:  0.000003348
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
77.9
age at onset
1
1
0
5.7
3.4
1
1
0
5.7
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
77.9
age at onset
0
5.7
3.4
0
5.7
3.4
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cystatin 9 like
VGNC:52080
740314
Mouse
MGI:1340053
13013
Rat
RGD:1311032
362231
Horse
cystatin-9
100058575
Pig
cystatin-9
100516302
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cystatin 9 like
Mouse
Rat
Horse
cystatin-9
Pig
cystatin-9
Publication Statistics
PubMed Score 4.63
PubMed score by year
PubTator Score 0.07
PubTator score by year
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Related Publications
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PMID
Year
Title