Protein Summary
Performs a specialized role during sperm development and maturation. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The encoded protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.84 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 214 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 44.84 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 214 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (60)
C1orf146
Novelty: 6.67972686
p_int: 0.999994251
p_ni: 0.000005562
p_wrong: 1.87e-7
Data Source: BioPlex
CDKN3
Family: Enzyme
Novelty: 0.00093913
p_int: 0.999944153
p_ni: 0.00005552
p_wrong: 3.27e-7
Data Source: BioPlex
FAM9C
Novelty: 0.86727989
p_int: 0.999821162
p_ni: 0.00005875
p_wrong: 0.000120088
Data Source: BioPlex
IQCF2
Novelty: 12.69230769
p_int: 0.999821162
p_ni: 0.00005875
p_wrong: 0.000120088
Data Source: BioPlex
SSBP1
Novelty: 0.01105839
p_int: 0.999362919
p_ni: 0.000103605
p_wrong: 0.000533476
Data Source: BioPlex
STK39
Family: Kinase
Novelty: 0.00548476
p_int: 0.997205486
p_ni: 0.002786645
p_wrong: 0.000007869
Data Source: BioPlex
SPCS3
Family: Enzyme
Novelty: 0.13677259
p_int: 0.994790263
p_ni: 0.005203753
p_wrong: 0.000005985
Data Source: BioPlex
ITIH2
Novelty: 0.04886358
p_int: 0.980790939
p_ni: 0.009041299
p_wrong: 0.010167762
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 5.7 | 3.4 | |||||
age at onset | 1 | 1 | 0 | 5.7 | 3.4 | ||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 5.7 | 3.4 | |||||
age at onset | 0 | 5.7 | 3.4 | ||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cystatin 8 | VGNC:9833 | 469900 | |||||
Macaque | cystatin 8 | 703172 | ||||||
Mouse | MGI:107161 | 13012 | ||||||
Rat | RGD:2434 | 29679 | ||||||
Dog | cystatin 8 | VGNC:39680 | 485735 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cystatin 8 | |||||
Macaque | cystatin 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cystatin 8 | |||||
Publication Statistics
PubMed Score 44.84
PubMed score by year
PubTator Score 67.75
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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