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Tbio
CST8
Cystatin-8

Protein Summary
Description
Performs a specialized role during sperm development and maturation. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The encoded protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246012
  • ENSP00000246012
  • ENSG00000125815

Symbol
  • CRES
  • CRES
  • CTES5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
cell line
0.63
tissue
0.48
chemical
0.43
phenotype
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.84   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.84   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
C1orf146
Tdark
Novelty:  6.67972686
p_int:  0.999994251
p_ni:  0.000005562
p_wrong:  1.87e-7
Data Source:  BioPlex
CDKN3
Tbio
Family:  Enzyme
Novelty:  0.00093913
p_int:  0.999944153
p_ni:  0.00005552
p_wrong:  3.27e-7
Data Source:  BioPlex
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.999821162
p_ni:  0.00005875
p_wrong:  0.000120088
Data Source:  BioPlex
IQCF2
Tdark
Novelty:  12.69230769
p_int:  0.999821162
p_ni:  0.00005875
p_wrong:  0.000120088
Data Source:  BioPlex
SSBP1
Tbio
Novelty:  0.01105839
p_int:  0.999362919
p_ni:  0.000103605
p_wrong:  0.000533476
Data Source:  BioPlex
PXDN
Tbio
Novelty:  0.00935722
p_int:  0.998331613
p_ni:  0.001668387
Data Source:  BioPlex
STK39
Tchem
Family:  Kinase
Novelty:  0.00548476
p_int:  0.997205486
p_ni:  0.002786645
p_wrong:  0.000007869
Data Source:  BioPlex
SPCS3
Tbio
Family:  Enzyme
Novelty:  0.13677259
p_int:  0.994790263
p_ni:  0.005203753
p_wrong:  0.000005985
Data Source:  BioPlex
ITIH2
Tbio
Novelty:  0.04886358
p_int:  0.980790939
p_ni:  0.009041299
p_wrong:  0.010167762
Data Source:  BioPlex
ARMC8
Tbio
Novelty:  0.06820746
p_int:  0.97736576
p_ni:  0.022634241
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.7
3.4
age at onset
1
1
0
5.7
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.7
3.4
age at onset
0
5.7
3.4
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cystatin 8
VGNC:9833
469900
Macaque
cystatin 8
703172
Mouse
MGI:107161
13012
Rat
RGD:2434
29679
Dog
cystatin 8
VGNC:39680
485735
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cystatin 8
Macaque
cystatin 8
Mouse
Rat
Dog
cystatin 8
Publication Statistics
PubMed Score 44.84
PubMed score by year
PubTator Score 67.75
PubTator score by year
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Related Publications
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PMID
Year
Title