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Tbio
CST6
Cystatin-M

Protein Summary
Description
Shows moderate inhibition of cathepsin B but is not active against cathepsin C. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312134
  • ENSP00000311313
  • ENSG00000175315
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
gene perturbation
0.65
disease
0.54
small molecule perturbation
0.51
biological term
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.39   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.39   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.99269158
p_ni:  0.007308407
p_wrong:  1.4e-8
Data Source:  BioPlex
ZSCAN12
Tdark
Family:  TF
Novelty:  0.33578207
p_int:  0.981872728
p_ni:  0.018115941
p_wrong:  0.000011332
Data Source:  BioPlex
CCDC103
Tbio
Novelty:  0.07857649
p_int:  0.952227042
p_ni:  0.047772906
p_wrong:  5.2e-8
Data Source:  BioPlex
ZDHHC23
Tbio
Family:  Enzyme
Novelty:  0.18700442
p_int:  0.950668203
p_ni:  0.047054528
p_wrong:  0.002277269
Score:  0.163
Data Source:  BioPlex,STRINGDB
FTH1
Tbio
Novelty:  0.000863
p_int:  0.941841949
p_ni:  0.057410934
p_wrong:  0.000747116
Data Source:  BioPlex
CA8
Tbio
Family:  Enzyme
Novelty:  0.0041859
p_int:  0.941512568
p_ni:  0.057718209
p_wrong:  0.000769224
Data Source:  BioPlex
TOX4
Tbio
Family:  TF
Novelty:  0.02486844
p_int:  0.939231037
p_ni:  0.06034179
p_wrong:  0.000427173
Score:  0.153
Data Source:  BioPlex,STRINGDB
CLEC5A
Tbio
Novelty:  0.01710591
p_int:  0.916684888
p_ni:  0.082543247
p_wrong:  0.000771864
Data Source:  BioPlex
CFAP97D1
Tdark
Novelty:  1.4689332
p_int:  0.913305989
p_ni:  0.083882171
p_wrong:  0.00281184
Score:  0.196
Data Source:  BioPlex,STRINGDB
EHF
Tbio
Family:  TF
Novelty:  0.00990018
p_int:  0.911731019
p_ni:  0.085684685
p_wrong:  0.002584296
Score:  0.381
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
PI3K-Akt Signaling Pathway
WikiPathways
Small cell lung cancer
Name
Explore in Pharos
Explore in Source
Vitamin D Receptor Pathway
Vitamin D Receptor Pathway
Vitamin D Receptor Pathway
PI3K-Akt Signaling Pathway
Small cell lung cancer
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
2
2
2
80
C-reactive protein measurement
3
2
3
73.9
blood protein measurement
2
2
2
73.4
body fat distribution
2
1
2
63.3
BMI-adjusted waist circumference
2
2
3
57.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
2
80
C-reactive protein measurement
3
73.9
blood protein measurement
2
73.4
body fat distribution
2
63.3
BMI-adjusted waist circumference
3
57.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cystatin E/M
466668
Macaque
cystatin E/M
714999
Mouse
MGI:1920970
73720
Rat
RGD:628799
171096
Dog
cystatin E/M
VGNC:39678
483719
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cystatin E/M
Macaque
cystatin E/M
Mouse
Rat
Dog
cystatin E/M
Publication Statistics
PubMed Score 47.39
PubMed score by year
PubTator Score 50.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title