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Tbio
CST4
Cystatin-S

Protein Summary
Description
This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited non-competitively. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and semina ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217423
  • ENSP00000217423
  • ENSG00000101441
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
cell line
0.66
gene perturbation
0.53
interacting protein
0.46
disease
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.65   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.65   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
CST1
Tbio
Novelty:  0.02399609
p_int:  0.999999322
p_ni:  4.6e-8
p_wrong:  6.32e-7
Score:  0.883
Data Source:  BioPlex,STRINGDB
PRKCE
Tchem
Family:  Kinase
Novelty:  0.00890161
p_int:  0.99947447
p_ni:  0.000525528
p_wrong:  2e-9
Data Source:  BioPlex
HINT2
Tbio
Novelty:  0.09560851
p_int:  0.998726921
p_ni:  0.001273063
p_wrong:  1.6e-8
Data Source:  BioPlex
GTF2B
Tbio
Novelty:  0.00179492
p_int:  0.997693703
p_ni:  0.002301692
p_wrong:  0.000004605
Data Source:  BioPlex
RHOBTB1
Tbio
Novelty:  0.02152609
p_int:  0.996585391
p_ni:  0.003414528
p_wrong:  8.1e-8
Data Source:  BioPlex
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.996470585
p_ni:  0.003148816
p_wrong:  0.000380599
Data Source:  BioPlex
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.995732113
p_ni:  0.004267833
p_wrong:  5.4e-8
Data Source:  BioPlex
KCNG4
Tclin
Family:  IC
Novelty:  0.07920772
p_int:  0.995570873
p_ni:  0.00442905
p_wrong:  7.7e-8
Score:  0.795
Data Source:  BioPlex,STRINGDB
ZNF491
Tdark
Family:  TF
Novelty:  4.75862069
p_int:  0.994953011
p_ni:  0.005046962
p_wrong:  2.8e-8
Data Source:  BioPlex
TNFRSF19
Tbio
Novelty:  0.01295599
p_int:  0.994060075
p_ni:  0.005905906
p_wrong:  0.000034019
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
77.9
age at onset
1
1
0
5.9
3.4
1
1
0
5.9
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
77.9
age at onset
0
5.9
3.4
0
5.9
3.4
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 111.65
PubMed score by year
PubTator Score 36.97
PubTator score by year
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Related Publications
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PMID
Year
Title