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Tbio
CST2
Cystatin-SA

Protein Summary
Description
Thiol protease inhibitor. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a secreted thiol protease inhibitor found at high levels in saliva, tears and seminal plasma. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304725
  • ENSP00000307540
  • ENSG00000170369
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.61
tissue
0.55
phenotype
0.41
protein domain
0.41
molecular function
0.38


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.5   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.5   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
COG2
Tbio
Novelty:  0.03109287
p_int:  0.99997093
p_ni:  0.000029069
Data Source:  BioPlex
GTF2B
Tbio
Novelty:  0.00179492
p_int:  0.999949419
p_ni:  0.000047327
p_wrong:  0.000003253
Score:  0.193
Data Source:  BioPlex,STRINGDB
RHOBTB1
Tbio
Novelty:  0.02152609
p_int:  0.999948943
p_ni:  0.000045698
p_wrong:  0.000005359
Score:  0.183
Data Source:  BioPlex,STRINGDB
PRKCE
Tchem
Family:  Kinase
Novelty:  0.00890161
p_int:  0.999948938
p_ni:  0.000051056
p_wrong:  5e-9
Data Source:  BioPlex
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999933057
p_ni:  0.000040019
p_wrong:  0.000026923
Data Source:  BioPlex
TNFRSF19
Tbio
Novelty:  0.01295599
p_int:  0.999811163
p_ni:  0.000179431
p_wrong:  0.000009406
Data Source:  BioPlex
KIR2DS2
Tdark
p_int:  0.999806941
p_ni:  0.000184903
p_wrong:  0.000008156
Data Source:  BioPlex
ZNF491
Tdark
Family:  TF
Novelty:  4.75862069
p_int:  0.999759023
p_ni:  0.000240589
p_wrong:  3.89e-7
Score:  0.165
Data Source:  BioPlex,STRINGDB
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.999555089
p_ni:  0.000416291
p_wrong:  0.00002862
Data Source:  BioPlex
HINT2
Tbio
Novelty:  0.09560851
p_int:  0.999498187
p_ni:  0.00050146
p_wrong:  3.53e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cystatin-D measurement
1
1
1
39.5
1
1
0
5.9
3.4
age at onset
1
1
0
5.9
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cystatin-D measurement
1
39.5
0
5.9
3.4
age at onset
0
5.9
3.4
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 48.50
PubMed score by year
PubTator Score 54.81
PubTator score by year
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Related Publications
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PMID
Year
Title