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Tbio
CST11
Cystatin-11

Protein Summary
Description
Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377007
  • ENSP00000366206
  • ENSG00000125831
  • ENST00000377009
  • ENSP00000366208

Symbol
  • CST8L
  • SC13
  • CST8L
  • CTES2
  • dJ322G13.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
cell line
0.71
cell type or tissue
0.4
biological process
0.38
tissue sample
0.36


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.78   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.78   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
NXT1
Tbio
Novelty:  0.02307435
Score:  0.834
Data Source:  STRINGDB
LCN9
Tdark
Novelty:  0.25490072
Score:  0.732
Data Source:  STRINGDB
LCN8
Tbio
Novelty:  0.02098116
Score:  0.721
Data Source:  STRINGDB
CST7
Tbio
Novelty:  0.03651959
Score:  0.685
Data Source:  STRINGDB
ACSS1
Tbio
Family:  Enzyme
Novelty:  0.02003886
Score:  0.668
Data Source:  STRINGDB
GZF1
Tbio
Family:  TF
Novelty:  0.15337347
Score:  0.652
Data Source:  STRINGDB
CST9
Tbio
Novelty:  0.08129086
Score:  0.595
Data Source:  STRINGDB
ADAM7
Tbio
Family:  Enzyme
Novelty:  0.02387438
Score:  0.577
Data Source:  STRINGDB
RNASE10
Tdark
Family:  Enzyme
Novelty:  0.1032541
Score:  0.538
Data Source:  STRINGDB
TPM3
Tbio
Novelty:  0.00108151
Score:  0.518
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at onset
1
1
0
5.7
6.4
Alzheimer disease
1
1
0
5.7
6.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at onset
0
5.7
6.4
Alzheimer disease
0
5.7
6.4
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cystatin 11
VGNC:6085
469899
Macaque
cystatin 11
654419
Mouse
MGI:1925490
78240
Rat
RGD:620589
245916
Dog
cystatin 11
VGNC:39677
606832
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cystatin 11
Macaque
cystatin 11
Mouse
Rat
Dog
cystatin 11
Publication Statistics
PubMed Score 49.78
PubMed score by year
PubTator Score 4.75
PubTator score by year
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Related Publications
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PMID
Year
Title