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Tbio
CST1
Cystatin-SN

Protein Summary
Description
Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. Thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304749
  • ENSP00000305731
  • ENSG00000170373
  • ENST00000398402
  • ENSP00000381439
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
cell line
0.73
cell type or tissue
0.73
small molecule perturbation
0.51
tissue
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.23   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.23   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
CST4
Tbio
Novelty:  0.00773554
p_int:  0.999999322
p_ni:  4.6e-8
p_wrong:  6.32e-7
Score:  0.883
Data Source:  BioPlex,STRINGDB
HINT2
Tbio
Novelty:  0.09560851
p_int:  0.999985029
p_ni:  0.000013918
p_wrong:  0.000001054
Data Source:  BioPlex
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999960755
p_ni:  0.000038204
p_wrong:  0.000001041
Data Source:  BioPlex
CTSH
Tchem
Family:  Enzyme
Novelty:  0.00336694
p_int:  0.999935913
p_ni:  0.000064087
Score:  0.348
Data Source:  BioPlex,STRINGDB
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.999775395
p_ni:  0.000153907
p_wrong:  0.000070698
Data Source:  BioPlex
GTF2B
Tbio
Novelty:  0.00179492
p_int:  0.999729722
p_ni:  0.000270161
p_wrong:  1.17e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
PLEKHG6
Tbio
Novelty:  0.15989022
p_int:  0.999721734
p_ni:  0.000128559
p_wrong:  0.000149707
Data Source:  BioPlex
RHOBTB1
Tbio
Novelty:  0.02152609
p_int:  0.999712574
p_ni:  0.00028739
p_wrong:  3.6e-8
Data Source:  BioPlex
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.999599976
p_ni:  0.000399938
p_wrong:  8.7e-8
Data Source:  BioPlex
UBTD2
Tbio
Novelty:  0.19609399
p_int:  0.999445675
p_ni:  0.000554273
p_wrong:  5.2e-8
Score:  0.235
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.9
3.4
age at onset
1
1
0
5.9
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.9
3.4
age at onset
0
5.9
3.4
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cystatin SN
VGNC:13839
740521
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cystatin SN
Publication Statistics
PubMed Score 51.23
PubMed score by year
PubTator Score 55.82
PubTator score by year
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Related Publications
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PMID
Year
Title