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Tbio
CSRP1
Cysteine and glycine-rich protein 1

Protein Summary
Description
Could play a role in neuronal development. This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340006
  • ENSP00000345079
  • ENSG00000159176
  • ENST00000367306
  • ENSP00000356275
  • ENST00000532460
  • ENSP00000434147
  • ENST00000533432
  • ENSP00000436792

Symbol
  • CSRP
  • CYRP
  • CRP
  • CRP1
  • CSRP
  • CYRP
  • D1S181E
  • HEL-141
  • HEL-S-286
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.98
disease perturbation
0.97
PubMedID
0.97
transcription factor binding site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.7   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.7   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
MTF1
Tbio
Family:  TF
Novelty:  0.01350821
Score:  0.908
Data Source:  STRINGDB
NUP214
Tbio
Novelty:  0.00924336
Score:  0.859
Data Source:  STRINGDB
ACTN1
Tbio
Novelty:  0.00654004
Score:  0.843
Data Source:  STRINGDB
MYL9
Tbio
Novelty:  0.00309239
Score:  0.786
Data Source:  STRINGDB
LMO3
Tbio
Novelty:  0.03437083
Score:  0.764
Data Source:  STRINGDB
MYH11
Tbio
Novelty:  0.00142474
Score:  0.697
Data Source:  STRINGDB
MED14
Tbio
Family:  Enzyme
Novelty:  0.01741917
Score:  0.695
Data Source:  STRINGDB
FLNA
Tbio
Novelty:  0.00156479
Score:  0.672
Data Source:  STRINGDB
LMO1
Tbio
Novelty:  0.01670419
Score:  0.672
Data Source:  STRINGDB
TAGLN
Tbio
Novelty:  0.00243855
Score:  0.64
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
MTF1 activates gene expression
Reactome
Response to metal ions
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
MTF1 activates gene expression
Response to metal ions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
0
8.5
68.6
balding measurement
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
0
8.5
68.6
balding measurement
1
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cysteine and glycine rich protein 1
VGNC:6739
457621
Macaque
cysteine and glycine rich protein 1
709693
Mouse
MGI:88549
13007
Rat
RGD:62053
29276
Dog
cysteine and glycine rich protein 1
VGNC:39675
607054
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cysteine and glycine rich protein 1
Macaque
cysteine and glycine rich protein 1
Mouse
Rat
Dog
cysteine and glycine rich protein 1
Publication Statistics
PubMed Score 52.70
PubMed score by year
PubTator Score 11.30
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title