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Tbio
CSRNP1
Cysteine/serine-rich nuclear protein 1

Protein Summary
Description
Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis. This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273153
  • ENSP00000273153
  • ENSG00000144655
  • ENST00000514182
  • ENSP00000422532

Symbol
  • AXUD1
  • TAIP3
  • AXUD1
  • URAX1
  • TAIP-3
  • CSRNP-1
  • FAM130B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor binding site profile
0.89
transcription factor
0.71
tissue sample
0.67
biological process
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.69   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.69   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
SCAI
Tbio
Novelty:  0.0021735
p_int:  0.99999714
p_ni:  0.00000286
Data Source:  BioPlex
AHDC1
Tdark
Novelty:  0.06647774
p_int:  0.99998817
p_ni:  0.000011829
p_wrong:  1e-9
Data Source:  BioPlex
SHARPIN
Tbio
Novelty:  0.0197352
p_int:  0.999853999
p_ni:  0.000142709
p_wrong:  0.000003292
Data Source:  BioPlex
TTLL5
Tbio
Family:  Enzyme
Novelty:  0.10212919
p_int:  0.994298451
p_ni:  0.004444647
p_wrong:  0.001256902
Data Source:  BioPlex
KANSL2
Tbio
Novelty:  0.08741608
p_int:  0.993610657
p_ni:  0.00587315
p_wrong:  0.000516193
Data Source:  BioPlex
MYCBP2
Tbio
Family:  Enzyme
Novelty:  0.00413684
p_int:  0.980583178
p_ni:  0.019416822
Data Source:  BioPlex
TAF5L
Tbio
Family:  Enzyme
Novelty:  0.29525944
p_int:  0.978846584
p_ni:  0.021153173
p_wrong:  2.43e-7
Data Source:  BioPlex
MCRS1
Tbio
Novelty:  0.03404119
p_int:  0.973955535
p_ni:  0.026036981
p_wrong:  0.000007483
Data Source:  BioPlex
ZNF92
Tbio
Family:  TF
Novelty:  0.05724663
p_int:  0.970224568
p_ni:  0.006993709
p_wrong:  0.022781723
Data Source:  BioPlex
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.929551867
p_ni:  0.070448133
Score:  0.187
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
60.5
platelet crit
1
1
1
57.8
platelet count
1
1
1
54.4
metabolic syndrome
1
1
1
15.8
monocyte percentage of leukocytes
1
1
1
7.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
60.5
platelet crit
1
57.8
platelet count
1
54.4
metabolic syndrome
1
15.8
monocyte percentage of leukocytes
1
7.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cysteine and serine rich nuclear protein 1
VGNC:8830
470794
Macaque
cysteine and serine rich nuclear protein 1
694328
Mouse
MGI:2387989
215418
Rat
RGD:1305999
363165
Dog
cysteine and serine rich nuclear protein 1
VGNC:39673
485596
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cysteine and serine rich nuclear protein 1
Macaque
cysteine and serine rich nuclear protein 1
Mouse
Rat
Dog
cysteine and serine rich nuclear protein 1
Publication Statistics
PubMed Score 11.69
PubMed score by year
PubTator Score 4.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title