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Tbio
CSPP1
Centrosome and spindle pole-associated protein 1

Protein Summary
Description
May play a role in cell-cycle-dependent microtubule organization. This gene encodes a centrosome and spindle pole associated protein. The encoded protein plays a role in cell-cycle progression and spindle organization, regulates cytokinesis, interacts with Nephrocystin 8 and is required for cilia formation. Mutations in this gene result in primary cilia abnormalities and classical Joubert syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262210
  • ENSP00000262210
  • ENSG00000104218
  • ENST00000519668
  • ENSP00000430092

Symbol
  • CSPP
  • CSPP
  • JBTS21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
transcription factor perturbation
0.88
virus perturbation
0.79
cell type or tissue
0.68
cellular component
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.69   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.69   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
GAN
Tbio
Novelty:  0.01069743
p_int:  0.99999972
p_ni:  2.8e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.999010523
p_ni:  0.000989475
p_wrong:  2e-9
Score:  0.71
Data Source:  BioPlex,STRINGDB
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.994876868
p_ni:  0.005120024
p_wrong:  0.000003109
Score:  0.834
Data Source:  BioPlex,STRINGDB
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.993596813
p_ni:  0.00639252
p_wrong:  0.000010668
Score:  0.674
Data Source:  BioPlex,STRINGDB
DCTN4
Tbio
Novelty:  0.10319227
p_int:  0.987007854
p_ni:  0.012992146
Score:  0.813
Data Source:  BioPlex,STRINGDB
DCTN3
Tbio
Novelty:  0.14551388
p_int:  0.986156786
p_ni:  0.013843213
p_wrong:  1e-9
Score:  0.795
Data Source:  BioPlex,STRINGDB
HOMER1
Tbio
Novelty:  0.00264721
p_int:  0.983670157
p_ni:  0.016283774
p_wrong:  0.000046069
Score:  0.477
Data Source:  BioPlex,STRINGDB
ACTR1B
Tbio
Novelty:  0.10014723
p_int:  0.977926192
p_ni:  0.022073808
Score:  0.72
Data Source:  BioPlex,STRINGDB
ATP23
Tbio
Family:  Enzyme
Novelty:  0.09823059
p_int:  0.945613856
p_ni:  0.000266555
p_wrong:  0.054119589
Score:  0.175
Data Source:  BioPlex,STRINGDB
NME7
Tbio
Family:  Enzyme
Novelty:  0.08546782
p_int:  0.928992157
p_ni:  0.071007828
p_wrong:  1.5e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Joubert Syndrome
WikiPathways
Joubert Syndrome
WikiPathways
Joubert Syndrome
WikiPathways
Joubert Syndrome
WikiPathways
Joubert Syndrome
Name
Explore in Pharos
Explore in Source
Joubert Syndrome
Joubert Syndrome
Joubert Syndrome
Joubert Syndrome
Joubert Syndrome
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
38.8
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosome and spindle pole associated protein 1
VGNC:898
472785
Macaque
centrosome and spindle pole associated protein 1
704476
Mouse
MGI:2681832
211660
Rat
RGD:1307055
362472
Dog
centrosome and spindle pole associated protein 1
VGNC:39672
477902
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosome and spindle pole associated protein 1
Macaque
centrosome and spindle pole associated protein 1
Mouse
Rat
Dog
centrosome and spindle pole associated protein 1
Publication Statistics
PubMed Score 41.69
PubMed score by year
PubTator Score 17.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title