You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CSNK2A1
Casein kinase II subunit alpha

Protein Summary
Description
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217244
  • ENSP00000217244
  • ENSG00000101266
  • ENST00000349736
  • ENSP00000339247
  • ENST00000400217
  • ENSP00000383076
  • ENST00000643660
  • ENSP00000495248
  • ENST00000644003
  • ENSP00000495387
  • ENST00000645623
  • ENSP00000495998
  • ENST00000646305
  • ENSP00000495902
  • ENST00000646477
  • ENSP00000495439
  • ENST00000646561
  • ENSP00000496569
  • ENST00000646814
  • ENSP00000495422
  • ENST00000647348
  • ENSP00000495912

Symbol
  • CK2A1
  • CKII
  • Cka1
  • Cka2
  • CK2A1
  • OCNDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
virus
1
viral protein
0.98
biological process
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 563.31   (req: < 5)
Gene RIFs: 264   (req: <= 3)
Antibodies: 682   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 563.31   (req: >= 5)
Gene RIFs: 264   (req: > 3)
Antibodies: 682   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 222
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0