CSNK1G1
Casein kinase I isoform gamma-1
Protein Summary
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN. This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE). [provided by RefSeq, Jul 2016]
- ENST00000303052
- ENSP00000305777
- ENSG00000169118
- ENST00000606225
- ENSP00000475325
- CK1gamma1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
histone modification site profile | 0.9 | ||
cell type or tissue | 0.84 | ||
microRNA | 0.82 | ||
transcription factor binding site profile | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.69 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 355 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.69 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 355 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 17
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0