Tclin CSNK1E Casein kinase I isoform epsilon

Protein Summary

Description

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. This locus represents naturally occurring readthrough transcription between the neighboring LOC400927 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene) and CSNK1E (casein kinase I isoform epsilon) genes on chromosome 22. The readthrough transcript encodes the same protein as the downstream gene product (casein kinase I isoform epsilon). [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• P49674
• CKI-epsilon

Gene Name

• CSNK1E

Ensembl ID

• ENST00000359867
• ENSP00000352929
• ENSG00000213923
• ENST00000396832
• ENSP00000380044
• ENST00000403904
• ENSP00000384074

Symbol

• LOC400927-CSNK1E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.99
kinase perturbation	0.99
transcription factor perturbation	0.88
small molecule	0.85
PubMedID	0.8

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Casein Kinase I Isoform Epsilon

DTO Classes

Protein / Kinase / Protein Kinase / Ck1 Group / Ck1 Family / Casein Kinase I Isoform Epsilon

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.13   (req: < 5)

Gene RIFs: 73   (req: <= 3)

Antibodies: 437   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.13   (req: >= 5)

Gene RIFs: 73   (req: > 3)

Antibodies: 437   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 230

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2