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Tdark
CSNK1A1L
Casein kinase I isoform alpha-like

Protein Summary
Description
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379800
  • ENSP00000369126
  • ENSG00000180138

Symbol
  • CK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
interacting protein
0.74
cell type or tissue
0.63
protein domain
0.58
pathway
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.16   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.16   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
FAM170A
Tdark
Novelty:  0.05778712
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.388
Data Source:  BioPlex,STRINGDB
AXIN2
Tchem
Novelty:  0.00273189
Score:  0.91
Data Source:  STRINGDB
AXIN1
Tbio
Novelty:  0.00175842
Score:  0.906
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.878
Data Source:  STRINGDB
SMO
Tclin
Family:  GPCR
Novelty:  0.03235855
Score:  0.866
Data Source:  STRINGDB
CSNK1A1
Tchem
Family:  Kinase
Novelty:  0.00636472
Score:  0.801
Data Source:  STRINGDB
GSK3B
Tclin
Family:  Kinase
Novelty:  0.00095115
Score:  0.778
Data Source:  STRINGDB
APC
Tchem
Novelty:  0.00168376
Score:  0.723
Data Source:  STRINGDB
APC2
Tbio
Novelty:  0.02034048
Score:  0.723
Data Source:  STRINGDB
PRKACG
Tchem
Family:  Kinase
Novelty:  0.11080061
Score:  0.695
Data Source:  STRINGDB
Pathways (21)
Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Gastric cancer
KEGG
Breast cancer
KEGG
Hepatocellular carcinoma
KEGG
Wnt signaling pathway
KEGG
Human papillomavirus infection
Name
Explore in Pharos
Explore in Source
Gastric cancer
Breast cancer
Hepatocellular carcinoma
Wnt signaling pathway
Human papillomavirus infection
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
0.8
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
casein kinase 1 alpha 1 like
VGNC:13078
467264
Macaque
casein kinase 1 alpha 1 like
695190
Species
Name
OMA
EggNOG
Inparanoid
Chimp
casein kinase 1 alpha 1 like
Macaque
casein kinase 1 alpha 1 like
Publication Statistics
PubMed Score 1.16
PubMed score by year
PubTator Score 143.92
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title