You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CSNK1A1
Casein kinase I isoform alpha

Protein Summary
Description
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261798
  • ENSP00000261798
  • ENSG00000113712
  • ENST00000377843
  • ENSP00000367074
  • ENST00000515768
  • ENSP00000421689

Symbol
  • CK1
  • CK1a
  • CKIa
  • HLCDGP1
  • PRO2975
  • HEL-S-77p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
transcription factor perturbation
1
hub protein
0.97
kinase perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.73   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 608   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.73   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 608   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0