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Tbio
CSGALNACT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

Protein Summary
Description
Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome X. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374466
  • ENSP00000363590
  • ENSG00000169826

Symbol
  • CHGN2
  • GALNACT2
  • CHGN2
  • ChGn-2
  • PRO0082
  • GALNACT2
  • GALNACT-2
  • beta4GalNAcT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.92
histone modification site profile
0.7
cellular component
0.61
microRNA
0.56
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.36   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.36   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
CSGALNACT1
Tbio
Family:  Enzyme
Novelty:  0.03463325
p_int:  0.999999847
p_ni:  1.53e-7
Score:  0.87
Data Source:  BioPlex,STRINGDB
MCOLN1
Tchem
Family:  IC
Novelty:  0.00442768
p_int:  0.999998962
p_ni:  0.000001001
p_wrong:  3.7e-8
Score:  0.161
Data Source:  BioPlex,STRINGDB
TRIM59
Tbio
Novelty:  0.04240864
p_int:  0.999997244
p_ni:  0.000002715
p_wrong:  4.2e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.999982586
p_ni:  0.000017414
Data Source:  BioPlex
GOSR2
Tbio
Novelty:  0.02447711
p_int:  0.999950801
p_ni:  0.000049199
Data Source:  BioPlex
CHSY1
Tbio
Family:  Enzyme
Novelty:  0.03515909
p_int:  0.999938661
p_ni:  0.000061334
p_wrong:  5e-9
Score:  0.928
Data Source:  BioPlex,STRINGDB
PLB1
Tbio
Family:  Enzyme
Novelty:  0.01628403
p_int:  0.999888948
p_ni:  0.000111052
Score:  0.158
Data Source:  BioPlex,STRINGDB
SLC30A5
Tbio
Family:  Transporter
Novelty:  0.02432633
p_int:  0.999746743
p_ni:  0.000253245
p_wrong:  1.2e-8
Data Source:  BioPlex
DPP6
Tbio
Family:  Enzyme
Novelty:  0.00435138
p_int:  0.999631913
p_ni:  0.000368085
p_wrong:  2e-9
Data Source:  BioPlex
MANEAL
Tdark
Family:  Enzyme
Novelty:  0.71535497
p_int:  0.999627804
p_ni:  0.000372078
p_wrong:  1.18e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Chondroitin sulfate biosynthesis (R-HSA-2022870)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Glycosaminoglycan metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (62)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
4
0
5.3
97.8
BMI-adjusted hip circumference
1
1
1
26.6
central corneal thickness
1
1
0
1.5
21.5
cigarettes per day measurement
1
1
1
15.8
insulin sensitivity measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.3
97.8
BMI-adjusted hip circumference
1
26.6
central corneal thickness
0
1.5
21.5
cigarettes per day measurement
1
15.8
insulin sensitivity measurement
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chondroitin sulfate N-acetylgalactosaminyltransferase 2
VGNC:5384
450416
Macaque
chondroitin sulfate N-acetylgalactosaminyltransferase 2
703703
Mouse
MGI:1926002
78752
Rat
RGD:1563660
297554
Dog
chondroitin sulfate N-acetylgalactosaminyltransferase 2
VGNC:39660
486786
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chondroitin sulfate N-acetylgalactosaminyltransferase 2
Macaque
chondroitin sulfate N-acetylgalactosaminyltransferase 2
Mouse
Rat
Dog
chondroitin sulfate N-acetylgalactosaminyltransferase 2
Publication Statistics
PubMed Score 13.36
PubMed score by year
PubTator Score 11.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title