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Tbio
CSGALNACT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

Protein Summary
Description
Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758). Moreover, is involved in the metabolism of aggrecan (By similarity). This gene encodes an enzyme that transfers N-acetylglucosamine (GalNAc) to the core tetrasaccharide linker and to elongating chondroitin sulfate chains in proteoglycans. Knockout of the orthologous mouse gene indicates that the protein is necessary for normal cartilage development and aggrecan metabolism. Mutations in this gene are associated with multiple sclerosis progression, and with mild skeletal dysplasia and joint laxity. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332246
  • ENSP00000330805
  • ENSG00000147408
  • ENST00000397998
  • ENSP00000381084
  • ENST00000454498
  • ENSP00000411816
  • ENST00000519222
  • ENSP00000428216
  • ENST00000522854
  • ENSP00000429809

Symbol
  • CHGN
  • GALNACT1
  • ChGn
  • ChGn-1
  • CSGalNAcT-1
  • beta4GalNAcT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
pathway
0.92
PubMedID
0.76
small molecule perturbation
0.7
biological process
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.11   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.11   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.999999847
p_ni:  1.53e-7
Score:  0.87
Data Source:  BioPlex,STRINGDB
SLC30A1
Tbio
Family:  Transporter
Novelty:  0.00528427
p_int:  0.999841512
p_ni:  0.000158485
p_wrong:  3e-9
Score:  0.669
Data Source:  BioPlex,STRINGDB
ARFGEF1
Tbio
Novelty:  0.16148196
p_int:  0.999784566
p_ni:  0.000215428
p_wrong:  6e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
TMEM214
Tdark
Novelty:  0.32604613
p_int:  0.998500532
p_ni:  0.001499468
Score:  0.248
Data Source:  BioPlex,STRINGDB
ARFGEF2
Tbio
Novelty:  0.05568966
p_int:  0.989909695
p_ni:  0.010090305
Score:  0.173
Data Source:  BioPlex,STRINGDB
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.983850498
p_ni:  0.016149502
Data Source:  BioPlex
GPRC5B
Tbio
Family:  GPCR
Novelty:  0.05128765
p_int:  0.982668795
p_ni:  0.016767006
p_wrong:  0.000564199
Score:  0.21
Data Source:  BioPlex,STRINGDB
TIMELESS
Tbio
Novelty:  0.0041528
p_int:  0.982144653
p_ni:  0.01784777
p_wrong:  0.000007577
Score:  0.2
Data Source:  BioPlex,STRINGDB
TMX4
Tbio
Novelty:  0.2628295
p_int:  0.871988527
p_ni:  0.12801147
p_wrong:  3e-9
Score:  0.392
Data Source:  BioPlex,STRINGDB
B3GAT3
Tbio
Family:  Enzyme
Novelty:  0.0289834
Score:  0.956
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Chondroitin sulfate biosynthesis (R-HSA-2022870)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Glycosaminoglycan metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
29
12
37
94.6
triglyceride measurement
19
15
28
94.3
sleep duration
2
2
2
73.1
body height
1
1
1
69.3
apolipoprotein A 1 measurement
2
5
5
65.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
37
94.6
triglyceride measurement
28
94.3
sleep duration
2
73.1
body height
1
69.3
apolipoprotein A 1 measurement
5
65.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
chondroitin sulfate N-acetylgalactosaminyltransferase 1
704901
Mouse
MGI:2442354
234356
Rat
RGD:1307618
306375
Dog
chondroitin sulfate N-acetylgalactosaminyltransferase 1
VGNC:39659
482831
Horse
chondroitin sulfate N-acetylgalactosaminyltransferase 1
VGNC:16900
100052192
Species
Name
OMA
EggNOG
Inparanoid
Macaque
chondroitin sulfate N-acetylgalactosaminyltransferase 1
Mouse
Rat
Dog
chondroitin sulfate N-acetylgalactosaminyltransferase 1
Horse
chondroitin sulfate N-acetylgalactosaminyltransferase 1
Publication Statistics
PubMed Score 33.11
PubMed score by year
PubTator Score 13.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title