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Tbio
CSF3
Granulocyte colony-stimulating factor

Protein Summary
Description
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225474
  • ENSP00000225474
  • ENSG00000108342
  • ENST00000394148
  • ENSP00000377704
  • ENST00000394149
  • ENSP00000377705

Symbol
  • C17orf33
  • GCSF
  • GCSF
  • CSF3OS
  • C17orf33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
biological term
0.94
gene perturbation
0.88
disease
0.86
cell type or tissue
0.77


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9460.62   (req: < 5)
Gene RIFs: 147   (req: <= 3)
Antibodies: 1146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9460.62   (req: >= 5)
Gene RIFs: 147   (req: > 3)
Antibodies: 1146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (327)
CSF3R
Tclin
Novelty:  0.00416485
Score:  0.993
Data Source:  Reactome,STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.987
Data Source:  STRINGDB
EPO
Tbio
Novelty:  0.00013701
Score:  0.981
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.965
Data Source:  STRINGDB
THPO
Tbio
Novelty:  0.00049701
Score:  0.956
Data Source:  STRINGDB
CSF2
Tbio
Novelty:  0.00010437
Score:  0.931
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.921
Data Source:  STRINGDB
CD34
Tbio
Novelty:  0.00005468
Score:  0.92
Data Source:  STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.906
Data Source:  STRINGDB
IL17A
Tclin
Novelty:  0.00011583
Score:  0.899
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
Pathways (23)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-10 signaling
Reactome
Other interleukin signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-10 signaling
Other interleukin signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (45)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
11
14
22
99.9
leukocyte count
11
13
27
99.7
myeloid white cell count
5
7
7
99.6
lymphocyte percentage of leukocytes
2
6
7
98.9
neutrophil percentage of leukocytes
2
5
6
98.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
22
99.9
leukocyte count
27
99.7
myeloid white cell count
7
99.6
lymphocyte percentage of leukocytes
7
98.9
neutrophil percentage of leukocytes
6
98.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
colony stimulating factor 3
VGNC:9417
454641
Macaque
colony stimulating factor 3
698961
Mouse
MGI:1339751
12985
Rat
RGD:2426
25610
Dog
colony stimulating factor 3
VGNC:39657
608246
Species
Name
OMA
EggNOG
Inparanoid
Chimp
colony stimulating factor 3
Macaque
colony stimulating factor 3
Mouse
Rat
Dog
colony stimulating factor 3
Publication Statistics
PubMed Score 9460.62
PubMed score by year
PubTator Score 8663.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title