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Tclin
CSF2RB
Cytokine receptor common subunit beta

Protein Summary
Description
High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000403662
  • ENSP00000384053
  • ENSG00000100368
  • ENST00000406230
  • ENSP00000385271

Symbol
  • IL3RB
  • IL5RB
  • CD131
  • IL3RB
  • IL5RB
  • SMDP5
  • CDw131
  • betaGMR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.92
PubMedID
0.92
disease perturbation
0.83
protein domain
0.73
biological term
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.44   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 656   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.44   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 656   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2